In Vitro Activity of Ozenoxacin against Quinolone-Susceptible and Quinolone-Resistant Gram-Positive Bacteria |
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| Authors: | Y. López M. Tato P. Espinal F. Garcia-Alonso D. Gargallo-Viola R. Cantón J. Vila |
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| Affiliation: | Barcelona Centre for International Health Research (CRESIB), Barcelona, Spaina;Department of Clinical Microbiology, Hospital Clínic, Faculty of Medicine, University of Barcelona, Barcelona, Spainb;Department of Clinical Microbiology, Hospital Universitario Ramón y Cajal and the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spainc;Ferrer Laboratories, Barcelona, Spaind |
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| Abstract: | In vitro activity of ozenoxacin, a novel nonfluorinated topical (L. D. Saravolatz and J. Leggett, Clin. Infect. Dis. 37:1210–1215, 2003) quinolone, was compared with the activities of other quinolones against well-characterized quinolone-susceptible and quinolone-resistant Gram-positive bacteria. Ozenoxacin was 3-fold to 321-fold more active than other quinolones. Ozenoxacin could represent a first-in-class nonfluorinated quinolone for the topical treatment of a broad range of dermatological infections. |
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