Dynamics of neutrophil-to-lymphocyte ratio can be associated with clinical outcomes of children with moderate to severe traumatic brain injury: A retrospective observational study |
| |
| Affiliation: | 1. Department of neurosurgery Kermanshah University of Medical Sciences, Imam Reza hospital, Kermanshah, Iran;2. Department of pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of neurosurgery, Shahid Beheshti University of Medical Sciences, Loghman Hakim hospital;4. Department of anesthesiology, Kermanshah University of Medical Sciences, Imam Reza hospital, Kermanshah,Iran;5. Clinical Research Development Center, Imam Reza hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran;6. Kermanshah University of Medical Sciences, Imam Reza hospital, Kermanshah, Iran;7. Wayne State University School of Medicine, Detroit, MI, USA;8. Department of neurosurgery, Kermanshah University of Medical Sciences, Imam Reza hospital, Kermanshah, Iran;1. St. Joseph University, Dept. of Orthopedic Surgery, Hotel Dieu de France Hospital, Alfred Naccache Blvd, Beirut, Lebanon;2. Foothills Medical Center, Department of Surgery, University of Calgary, Canada;3. 0490 McCaig Tower, Foothills Medical Center, 3134 Hospital Dr NW, Calgary, Alberta T2N 5A1, Canada;1. Harvard Medical School Orthopedic Trauma Initiative, Brigham and Women''s hospital, Boston, United States;2. St. Antonius Hospital, Dpt. of Trauma Surgery, Utrecht, the Netherlands;3. Leiden University Medical Center, Dpt. of Clinical Epidemiology, Leiden, the Netherlands;4. Leiden University Medical Center, Dpt. of Biomedical Data Sciences, Leiden, the Netherlands;1. Servicio de Medicina Intensiva, Spain;2. Hospital Universitario 12 de Octubre, Madrid, Spain;3. Trinity College Dublin, School of Medicine. CLOD Dublin Midlands Hospital group, Dublin, EIRE;4. Intensive Care Medicine, Spain;5. Biochemistry Department, Spain;1. Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Orthopedics and Trauma Surgery, Turkey;2. Yeditepe University Hospital, Department of Physical Medicine and Rehabilitation, Turkey;1. Department of Obstetrics and Gynecology, Kitasato University Medical Center, Arai 6-100, Kitamoto-shi, Saitama 364-8501, Japan;2. Scientifics Research WorkS Peer Support Group (SRWS-PSG), Osaka, Japan;3. Department of Psychiatry, Seichiryo Hospital, Tsurumai 4-16-27, Showa-ku, Nagoya 466-0064, Japan;4. Department of Psychiatry, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8560 Japan;5. Department of General Medicine, Taragi Municipal Hospital, 4210 Taragi, Taragi-machi, Kuma-gun, Kumamoto 868-0598, Japan;6. Department of Health Research Methods, Evidence & Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada;7. Department of Orthopaedics, Teikyo University School of Medicine, 1-2-11 Kaga, Itabashi-ku, Tokyo 174-0054, Japan;1. Consultant Paediatric Orthopaedic Surgeon, Department of Paediatric Orthopaedics, Paediatric Division, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom;2. Higher Orthopaedic Trainee, Department of Paediatric Orthopaedics, Paediatric Division, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom;3. Higher Orthopaedic Trainee, Department of Paediatric Orthopaedics, Paediatric Division, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom;4. Consultant Paediatric Orthopaedic Surgeon, Department of Paediatric Orthopaedics, Paediatric Division, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom |
| |
| Abstract: | BackgroundThe neutrophil to lymphocyte ratio (NLR) has been reported to be associated with clinical outcomes of patients with severe traumatic brain injury (TBI). This study aimed to evaluate the correlation between the dynamics of NLR and clinical outcomes of pediatric patients with moderate to severe TBI.MethodsWe retrospectively evaluated the clinical data of a total of 374 pediatric patients with moder-ate to severe TBI who were treated in our department between May 2016 and May 2020.Clinical and laboratory data including the NLR upon admission and the NLR on hospital day four were collected. Poor clinical outcome was defined as Glasgow Outcome Scale (GOS) of 1–3. Multivariable logistic regression analyses were performed to investigate the correlation between the dynamics of NLR and clinical outcome.ResultsThree hundred seventy-four pediatric patients (mean age 7.37 ± 3.11, 52.7% male) were evaluated. Based on the ROC curves, a value of 5 was determined as the NLR cut-off value. The corresponding cutoff value for delta NLR was 1.The Glasgow Coma Scale (GCS) (OR, 3.42; 95% CI: 1.88–5.28; P <0.001), the light reflex (OR, 1.79; 95% CI: 1.34- 2.84; P = 0.027), the Rotterdam CT score (OR, 2.71; 95% CI: 1.72–4.13; P = 0.021), and delta NLR (OR, 1.71; 95% CI: 1.13- 2.52; P = 0.034) were identified as independent predictors for unfavorable outcomes in multivariable logistic regression analysis.ConclusionsThe result of the present study suggest that delta NLR could be a predictor of poor clinical outcome of pediatrics with moderate to severe TBI. This cost-effective and easily available biomarker could be used to predict clinical outcomes in these patients. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
