| 阿苯哒唑在猪囊尾蚴病患者体内吸收和排泄的初步研究 |
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| 引用本文： | 赵冠宏,许炽标.阿苯哒唑在猪囊尾蚴病患者体内吸收和排泄的初步研究[J].中国现代医药杂志,2002,4(3):4-5. |
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| 作者姓名： | 赵冠宏 许炽标 |
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| 作者单位： | 100050,北京,首都医科大学附属北京友谊医院 |
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| 摘 要： | 目的建立一个简便、快速的药物监测方法,为临床治疗用药提供更可靠的依据。方法应用高压液相色谱法(HPLC)检测人体血浆、脑脊液、尿液及粪便中阿苯哒唑(ABZ)及其代谢产物的含量。结果猪囊尾蚴病患者口服ABZ后平均约有11%的原形药物(ABZ)随粪便排出,未测到血浆、脑脊液及尿液中的ABZ,但在血浆、脑脊液、尿液及粪便中均可同时测到其代谢物阿苯哒唑亚砜(ABZSX)和阿苯哒唑砜(ABZSN)。结论ABZ被人体吸收后可迅速代谢为ABZSX及ABZSN,后两者是抗寄生虫的有效成分。
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| 关 键 词： | 高压液相色谱法 阿苯哒唑 阿苯哒唑亚砜 阿苯哒唑砜 |
| 修稿时间： | 2002年1月9日 |
Preliminary studies on the absorption and excretion of albendazole in patients with cysticercosis cellulosae |
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| Zhao Guanhong,Xu Zhibiao.Preliminary studies on the absorption and excretion of albendazole in patients with cysticercosis cellulosae[J].Modern Medicine Journal of China,2002,4(3):4-5. |
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| Authors: | Zhao Guanhong Xu Zhibiao |
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| Institution: | Zhao Guanhong,Xu Zhibiao. Beijing Friendship Hospital,Beijing 100050 |
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| Abstract: | Objective To explore the mechanism about working of ABZ and investigate it clinically pharmacodynamics.Methods HPLC has been used to detected the absorption and excretion of ABZ in patients with cysticercosis cellulosae. Results 11%of the primary drug was excreted from faeces, while no primary drug was found in the blood plasma, CSF,urine and faeces. ABZSX and ABZSN weredetected in all samples.Conclusion When ABZ was taken by patients orally, it was quickly metabolized into intermediate products ABZSX and ABZSN. The latter two have anti parasitic effects. |
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| Keywords: | High performance liquid chromatography(HPLC) Albendazole(ABZ) Albendazole sulfoxide(ABZSX) Albendazole sulfone(ABZSN) |
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