无症状性脑梗死患者认知功能障碍与抑郁和梗死部位的关系

目的 :探讨无症状性脑梗死 (ACI)患者的认知功能障碍与抑郁和梗死部位、数量的关系。方法 :选择 5 6例ACI患者作为研究对象 ,用修订韦氏成人智力量表和记忆量表、汉密顿抑郁量表等方法检测。结果 :1.双侧梗死组VIQ、FIQ及MQ显著低于右侧梗死组 (P <0 .0 5～ 0 .1) ,左侧梗死组VIQ、FIQ显著低于右侧梗死组 ;2 .皮质合并皮质下梗死组、皮质梗死组MQ显著低于皮质下梗死组 (P <0 .0 1) ;3.多灶梗死组VIQ、PIQ、FIQ及MQ分均显著低于单灶梗死组 (P <0 .0 5～ 0 .0 1) ;4 .抑郁组各智商及MQ显著低于正常组 (P <0 .0 1) ,非抑郁组VIQ显著低于正常组 (P<0 .0 5 )。抑郁组MQ显著低于非抑郁组 (P <0 .0 1) ,抑郁组和非抑郁组各智商比较未见显著差异。结论 :双侧梗死、皮质合并皮质下梗死、多发性梗死及抑郁的患者更易产生认知功能障碍。

Cognitive Dysfunction of Asymptomatic Cerebral Infarction and Its Relation to Depression and Location

Objective:To study the relation between cognitive dysfunction and depression and location of brain infarct in patients with asymptomatic cerebral infarction(ACI).Methods:Fifty-six patients with ACI demonstrated by CT or MRI scan were tested with WAIS-RC,WMS-RC and HAMD.Results:Patients with bilateral infarction had lower verbal intelligence quotient(VIQ),full intelligence quotient (FIQ),and memory quotient(MQ)than patients with right infarction(P<0.05 or 0.01).MQ in patients with cortex and cortex combined subcortex infarction were significantly lower than those in patients with subcortex infarction( P <0.01).VIQ,PIQ(Performance IQ),FIQ and MQ in patients with multiple infarction were significantly lower than those in patients with single focus( P <0.05 or 0.01).Patients with depression had lower IQ and MQ than the normal control( P <0.01).Patients without depression had lower scores in VIQ than the normal control( P <0.05).Patients with depression had lower MQ than those without( P <0.01).There was no significant difference of IQ between patients with depression and those without( P >0.05).Conclusion:Patients with bilateral infarction,cortex combined subcortex infarction,multiple infarction and depression have more cognitive dysfunction.