Epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly: what we know so far |
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Authors: | Castillo Jorge J Beltran Brady E Miranda Roberto N Paydas Semra Winer Eric S Butera James N |
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Affiliation: | The Miriam Hospital, 164 Summit Avenue, Providence, Rhode Island 02906, USA. jcastillo@lifespan.org |
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Abstract: | Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a "provisional" entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. We will review and discuss the incidence of EBV expression in DLBCL, the pathogenesis behind EBV-driven malignant transformation of B cells, the different EBV latency patterns associated with DLBCL, the distinct pathologic characteristics of EBV-positive DLBCL, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity, which is characterized by a suboptimal response to therapy and poor survival rate. |
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Keywords: | EBV Epstein‐Barr virus Diffuse large B‐cell lymphoma DLBCL Elderly Review |
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