Hypoxia Increases Serum Amyloid A3 (SAA3) in Differentiated 3T3-L1 Adipocytes |
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Authors: | Edson Mendes de Oliveira Silvana Sandri Franciele Hinterholz Knebel Caroline Garcia Iglesias Contesini Ana Campa Fabíola Branco Filippin-Monteiro |
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Institution: | 1. Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of S?o Paulo, Av. Prof. Lineu Prestes, 580, S?o Paulo, CEP 05508-900, Brazil
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Abstract: | Hypoxia has been implicated as a possible cause of adipose tissue inflammation. Furthermore, the acute phase protein serum amyloid A (SAA) has been associated with the modulation of the adipogenic process, and it is well-known that obese individuals have increased levels of SAA. The effect of hypoxia in the expression and production of SAA was examined in murine 3T3-L1 adipocytes. Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (threefold in 48 h), in fully differentiated 3T3-L1, followed by reestablishment of gene expression to basal levels after 24 h of reoxygenation. Hypoxia-induced SAA may be one of the key molecules to the development of the inflammatory response in adipose tissue. |
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