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Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
Authors:Tanmoy Mondal  Prasanna Kumar Juvvuna  Agnete Kirkeby  Sanhita Mitra  Subazini Thankaswamy Kosalai  Larissa Traxler  Falk Hertwig  Sara Wernig-Zorc  Caroline Miranda  Lily Deland  Ruth Volland  Christoph Bartenhagen  Deniz Bartsch  Sashidhar Bandaru  Anne Engesser  Santhilal Subhash  Tommy Martinsson  Helena Carén  Chandrasekhar Kanduri
Affiliation:1. Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden;2. Department of Experimental Pediatric Oncology, University Children''s Hospital, and Center for Molecular Medicine (CMMC), Medical Faculty, University of Cologne, 50937 Cologne, Germany;3. Childhood Cancer Research Unit, Astrid Lindgren Children''s Hospital, Karolinska University Hospital, 17176 Stockholm, Sweden;4. Center for Applied Medical Research (CIMA), University of Navarra, Pio XII, 55, 31008 Pamplona, Spain;5. Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden;6. Center for Molecular Medicine Cologne, Institute for Neurophysiology, The Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Cologne, Germany;7. Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden;8. Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden;9. Sahlgrenska Cancer Center, Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden;10. Department of Pediatric Oncology and Hematology, Charité – Universitätsmedizin Berlin, 10117 Berlin, Germany;11. Danish Stem Cell Center (DanStem), University of Copenhagen, 2200 Copenhagen, Denmark
Abstract:
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  • Keywords:long noncoding RNA  neuroblastoma  USP36  CHD7  lncRNA  neuronal differentiation  ubiquitination
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