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Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
Authors:Rinath Jeselsohn  Johann S Bergholz  Matthew Pun  MacIntosh Cornwell  Weihan Liu  Agostina Nardone  Tengfei Xiao  Wei Li  Xintao Qiu  Gilles Buchwalter  Ariel Feiglin  Kayley Abell-Hart  Teng Fei  Prakash Rao  Henry Long  Nicholas Kwiatkowski  Tinghu Zhang  Nathanael Gray  Myles Brown
Institution:1. Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA 02210, USA;2. Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02210, USA;3. Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA 02210, USA;4. Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA;5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA;6. Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute and Harvard School of Public Health, Boston, MA 02215, USA;7. Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02215, USA;8. PamGene International BV, Hertogenbosch 5211, the Netherlands;9. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Abstract:
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  • Keywords:breast cancer  estrogen receptor  endocrine therapy resistance  cistrome  CDK7  estrogen recptor mutations
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