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Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1
Authors:Chia-Wei Li  Seung-Oe Lim  Ezra M. Chung  Yong-Soo Kim  Andrew H. Park  Jun Yao  Jong-Ho Cha  Weiya Xia  Li-Chuan Chan  Taewan Kim  Shih-Shin Chang  Heng-Huan Lee  Chao-Kai Chou  Yen-Liang Liu  Hsin-Chih Yeh  Evan P. Perillo  Andrew K. Dunn  Chu-Wei Kuo  Mien-Chie Hung
Affiliation:1. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA;2. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;3. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;4. Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea;5. Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA;6. Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA;7. Core Facilities for Protein Structural Analysis, Academia Sinica, Taipei 115, Taiwan;8. Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan;9. Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan;10. Department of Biotechnology, Asia University, Taichung 413, Taiwan;11. STCube Pharmaceuticals, Inc., 401 Professional Drive, Suite 250, Gaithersburg, MD 20879, USA;12. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA
Abstract:
Keywords:glycosylation  PD-L1  PD-1  B3GNT3  immunosuppression  antibody-drug conjugate  immune checkpoint blockade  TNBC  receptor internalization  immunotherapy
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