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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
Authors:Chaoyang Sun  Jun Yin  Yong Fang  Jian Chen  Kang Jin Jeong  Xiaohua Chen  Christopher P Vellano  Zhenlin Ju  Wei Zhao  Dong Zhang  Yiling Lu  Funda Meric-Bernstam  Timothy A Yap  Maureen Hattersley  Mark J O&#x;Connor  Huawei Chen  Stephen Fawell  Shiaw-Yih Lin  Gordon B Mills
Institution:1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;3. Aurora Research Institute, Milwaukee, WI 53202, USA;4. Department of General Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310000, China;5. Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;6. Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;7. IMED Oncology, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, USA;8. AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK;9. Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Abstract:
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  • Keywords:BRD4 inhibitor  homologous recombination  PARP inhibitor  CtBP-interacting protein  CtIP
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