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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
Authors:Hiroyoshi Kunimoto  Cem Meydan  Abbas Nazir  Justin Whitfield  Kaitlyn Shank  Franck Rapaport  Rebecca Maher  Elodie Pronier  Sara C Meyer  Francine E Garrett-Bakelman  Martin Tallman  Ari Melnick  Ross L Levine  Alan H Shih
Institution:1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;3. Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Institute for Computational Biomedicine and Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065, USA;5. University of Connecticut School of Medicine, Farmington, CT 06032, USA;6. Division of Hematology, University Hospital Basel, 4031 Basel, Switzerland;7. Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland;8. Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medical College, New York, NY 10065, USA;9. Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA;10. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA;11. Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;12. Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
Abstract:
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  • Keywords:leukemia biology  cancer epigenetics  targeted therapeutics
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