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Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis
Authors:Lai Man Natalie Wu  Yaqi Deng  Jincheng Wang  Chuntao Zhao  Jiajia Wang  Rohit Rao  Lingli Xu  Wenhao Zhou  Kwangmin Choi  Tilat A. Rizvi  Marc Remke  Joshua B. Rubin  Randy L. Johnson  Thomas J. Carroll  Anat O. Stemmer-Rachamimov  Jianqiang Wu  Yi Zheng  Mei Xin  Q. Richard Lu
Affiliation:1. Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH 45229, USA;2. Key Laboratory of Birth Defects, Children''s Hospital of Fudan University, Shanghai, China;3. Departments of Pediatric Oncology, Neuropathology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf 40225, Germany;4. Department of Pediatric Neuro-Oncogenomics, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Düsseldorf 40225, Germany;5. Departments of Pediatrics and Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA;6. Department of Cancer Biology, MD Anderson Cancer Center, University of Texas, Houston, TX 77054, USA;7. Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;8. Department of Pathology, Massachusetts General Hospital, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, MA 02114, USA
Abstract:
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  • Keywords:peripheral nerve sheath tumor  MPNST  tumor suppressor  Schwann cells  Lats1/2  hippo signaling  TAZ  YAP  murine models  PDGF signaling
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