| 纤维蛋白刺激平滑肌细胞的增生和胞内胆固醇堆积 |
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| 引用本文： | 王雪青,董林旺,唐朝枢,苏静怡. 纤维蛋白刺激平滑肌细胞的增生和胞内胆固醇堆积[J]. 北京大学学报(医学版), 1995, 0(5) |
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| 作者姓名： | 王雪青 董林旺 唐朝枢 苏静怡 |
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| 作者单位： | 北京医科大学心血管基础研究所 |
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| 摘 要： | 在培养的家兔主动脉平滑肌细胞上观察到，纤维蛋白能够剂量依赖性地刺激平滑肌细胞增生，刺激胶原合成，增加细胞内胆固醇堆积，提示纤维蛋白很可能参与了动脉粥样硬化的发生。
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| 关 键 词： | 肌，平滑／药物作用，纤维蛋白／药理学，胆固醇／代谢 |
PROMOTING EFFECTS OF FIBRIN ON PROLIFERATION AND CHOLESTEROL ACCUMULATION OF SMOOTH MUSCLE CELLS |
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| Laboratory of Shock Pathophysiology. PROMOTING EFFECTS OF FIBRIN ON PROLIFERATION AND CHOLESTEROL ACCUMULATION OF SMOOTH MUSCLE CELLS[J]. Journal of Peking University. Health sciences, 1995, 0(5) |
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| Authors: | Laboratory of Shock Pathophysiology |
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| Affiliation: | Laboratory of Shock Pathophysiology,Institute of Cardiovascular Research Wang Xueqing,et al |
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| Abstract: | n cultured smooth muscle cells(SMC) isolated from rabbit aortae, following findings were observed :fibrin stimulated the proliferation of SMC and the synthesis of collagen as well as elevated intracellular cholesterol accu-mulation in a dose-dependent manner.These data indicate that fibrin might be involved in the pathogenesis of atherosclerosis. |
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| Keywords: | Headings Muscle smooth/drug eff Fibrin/pharmacol Cholesterol/metab |
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