| 冷水七中5种活性三萜皂苷对小鼠的半数致死量测定 |
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| 引用本文： | 陈昶,周雪峰,张勇慧,皮慧芳,阮汉利,吴继洲. 冷水七中5种活性三萜皂苷对小鼠的半数致死量测定[J]. 中华中医药学刊, 2007, 25(6): 1124-1126 |
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| 作者姓名： | 陈昶 周雪峰 张勇慧 皮慧芳 阮汉利 吴继洲 |
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| 作者单位： | 华中科技大学同济药学院天然药物化学教研室,湖北,武汉,430030 |
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| 摘 要： | 目的：研究冷水七中5种活性三萜皂苷的急性毒性和对小鼠的半数致死量（LD50）。方法：取昆明种小鼠,完全随机平均分组后腹腔注射给药,分别给予不同浓度的三萜皂苷A、B、C、D、E。以小鼠急性死亡率为指标,求各三萜皂苷的LD50和LD50的95%可信区间。结果三萜皂苷A、B、C、D、E对小鼠的LD50分别为15.4928,23.7719,24.7016,24.7813和15.9727 mg/kg。结论：三萜皂苷A、E的毒性较大,而B、C、D的毒性相对较小。实验结果为进一步研究开发提供了毒性依据。
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| 关 键 词： | 冷水七 三萜皂苷 毒理学 |
| 文章编号： | 1673-7717（2007）06-1124-03 |
| 收稿时间： | 2007-01-01 |
| 修稿时间： | 2007-01-01 |
LD50 Determination of Five Triterpenoid Saponins from Impatiens Prizellii in Mice |
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| CHEN Chang,ZHOU Xue-feng,ZHANG Yong-hui,PI Hui-fang,RUAN Han-li,WU Ji-zhou. LD50 Determination of Five Triterpenoid Saponins from Impatiens Prizellii in Mice[J]. Chinese Archives of Traditional Chinese Medicine, 2007, 25(6): 1124-1126 |
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| Authors: | CHEN Chang ZHOU Xue-feng ZHANG Yong-hui PI Hui-fang RUAN Han-li WU Ji-zhou |
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| Affiliation: | School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China |
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| Abstract: | Objective:To determine the acute toxicity and LD50 of five triterpenoid saponins from Impatiens pritzellii Hook.f.var.hupehensis Hook.f.in mice.Methods:Mice of the Kunming strain were randomly divided into 26 groups with 10 animals in each group.Mice of different groups were given each an intraperitoneal injection of five triterpenoid saponins in different doses separately.Values of LD50 and 95% confidence interval of the 5 drugs were then calculated with Bliss method.Results:The LD50 of Triterpenoid SaponinA,B,C,D,E were shown to be 15.4928,23.7719,24.7016,24.7813and15.9727mg/kg,respectively.Conclusion:The Triterpenoid SaponinA,E were shown to have higher toxicity and Triterpenoid SaponinB,C,D were lower relatively.The experimental result provided toxicity data for further research and development. |
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| Keywords: | LD50 |
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