载药磷酸钙骨水泥治疗慢性骨髓炎研究进展

抗生素缓释系统具有局部抗生素浓度高，全身毒副作用小，缓慢释放，持续时间长等优点，已逐渐成为治疗慢性骨髓炎的一种重要方法。载药磷酸钙骨水泥（CPC）具有药物载体和修复骨缺损的双重作用，且能诱导骨的生长并同步降解，是一种理想的安全可靠的抗生素缓释载体材料。在彻底病灶清除的基础上用载药CPC植入骨缺损处为治疗慢性骨髓炎的一种理想的行之有效的方法，具有操作简便、效果佳、住院时间短等优点。本文拟就载药磷酸钙骨水泥的生物特性、实验研究和临床应用等方面作一综述。

Treatment of chronic osteomyelitis with antibiotic -loaded calcium phosphate cement

The antibiotic delayed release system which has the characteristics of high local antibiotic concentration,few adverse effects,slow release and long duration,has became one of important methods of treating chronic osteomyelitis. Because of its double action as drug carrier and bone repair material which can induce bone growth and degrade synchronously,drug impregnated calcium phosphate cement(diCPC)is an ideal and safe antibiotic slow release carrier. After clearing focus thoroughly,defect implant with diCPC is an effective method,which has the virtues of convenient operation, good effects and short staying time etc. This paper aims to summarize the biological properties,experimental study and clinical application of diCPC.