男性2型糖尿病患者血清维生素D水平与周围神经病变的相关性

目的：探讨男性2型糖尿病（ Type 2 diabetes mellitus,T2DM）患者血清中25羟维生素D（25-hy-droxyvitamin D，25（OH）D）水平及其与周围神经病（diabetic peripheral neuropathy，DPN）的相关性。方法选取遵义医学院附属医院内分泌科住院部的男性2型糖尿病患者230例，根据有无周围神经病变分为非周围神经病变组（NDPN,n=107）和糖尿病周围神经病组（DPN,n=123），同时选取我院体检中心的健康男性50例，作为正常对照组（NC，n=50），分析三组间血清25（OH）D、空腹静脉血糖（FBG）、空腹胰岛素（ FIns）、血脂谱[甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）及高密度脂蛋白（HDL-C）]水平；将三组间25（OH）D的缺乏程度做比较。结果（1）DPN组血清25（OH）D水平较NDPN组明显降低（P＜0.05），NDPN组血清25（OH）D水平较NC组明显降低（P＜0.05）；（2）Pearson相关分析显示血清25（OH）D水平与FIns、HDL-C水平呈正相关（P＜0.05），与HbA1c水平呈负相关（P＜0.05）。结论血清25（OH）D的缺乏与T2DM和DPN的发生密切相关。

The Correlation between the Level of Vitamin D and Diabetic Peripheral Neuropathy in Male Patients with Type 2 Diabetes Mellitus

Objective To explore the correlation between the level of 25-hydroxyvitamin D (25(OH)D) and diabetic peripheral neu-ropathy (DPN) in male patients with type 2 diabetes mellitus (T2DM). Methods 230 male cases with T2DM hospitalized in Department of Endocrinology, the Affiliated Hospital to Zunyi Medical College were selected and divided into 2 groups:NDPN group (cases with no DPN, n=107) and DPN group (cases with DPN, n=123);50 normal cases were selected to be the control group;analysis was made to 25(OH)D, fasting blood glucose (FBG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) of the cases in the 3 groups and a comparison of 25(OH)D deficiency was made among the 3 groups. Results The level of 25(OH)D of the cases in DPN group was much lower than that of the cases in NDPN group (P<0.05) while the level of 25(OH)D of the cases in NDPN group was much lower than that in control group(P<0.05);Pearson Correlation Analy-sis showed that there existed a positive correlation between the level of 25(OH)D and the level of Fins and HDL-C (P<0.05) while a neg-ative correlation between the level of 25(OH)D and the level of HbAlc (P<0.05). Conclusions 25(OH)D deficiency is closely correlated to the occurrence of T2DM and DPN.