子宫内膜癌淋巴结转移的危险因素分析

目的：分析子宫内膜癌淋巴结转移的危险因素，为合理治疗子宫内膜癌提供理论依据。方法回顾性分析236例经术后病理学确诊为子宫内膜癌患者的临床和病理学资料，对子宫内膜癌淋巴结转移可能的相关危险因素进行单因素及多因素回归分析。结果单因素分析显示，子宫内膜癌淋巴结转移与CA12-5水平、肿瘤体积、病理类型、病理分级、肌层浸润深度、宫颈及附件受累情况和雌激素受体表达有关。多因素Logistic回归分析显示，CA12-5水平、肿瘤直径、病理类型、病理分级、肌层浸润和附件受累情况是淋巴结转移的独立危险因素。结论较高水平的CA12-5、肿瘤直径＞2cm、中低分化内膜样癌、深肌层浸润和附件浸润是子宫内膜癌淋巴结转移的独立危险因素。

Risk Factors of Lymph Node Metastasis in Endometrial Carcinoma

Objective To analyze the risk factors of lymph node metastasis in endometrial carcinoma so as to provide the theoretical basis for rational treatment of endometrial carcinoma. Methods A retrospective analysis was made to the clinical and pathological data of 236 cases with endometrial carcinoma pathologically confirmed after surgery;univariate analysis and multivariate regression analysis were performed to evaluate the related risk factors of lymph node metastasis in endometrial carcinoma. Results The univariate analysis showed that the level of CA12-5, the size of tumor, pathological types, pathological grades, depth of myometrial invasion, cervical and nexal involvement and the estrogen receptor expression were related to lymph node metastasis while the multivariate regression analysis showed that the level of CA12-5, the size of the tumor, pathological grades, depth of myometrial invasion and the nexal involvement were the independent risk factors of lymph node metastasis. Conclusions The elevated level of CA12-5, tumor with a diameter over 2 cm, moderately or poorly differentiated endometrioid carcinoma, deep myometrial and nexal invasion are the independent risk factors of lymph node metastasis in endometrial carcinoma.