侵袭性纤维瘤基因的相关性研究 |
| |
引用本文: | 朱立宁,马瑞雪. 侵袭性纤维瘤基因的相关性研究[J]. 中华小儿外科杂志, 2016, 0(2): 156-160. DOI: 10.3760/cma.j.issn.0253-3006.2016.02.017 |
| |
作者姓名: | 朱立宁 马瑞雪 |
| |
作者单位: | 复旦大学附属儿科医院骨科,上海,201102 |
| |
摘 要: | 侵袭性纤维瘤(Aggressive fibromatosis,AF)又称硬性纤维瘤,局部侵袭性生长,但无远处转移能力的软组织肿瘤,手术切除是主要治疗方法,复发率高.发病机制不明确,早期检测也一直无法解决.文献报道突变的p-catenin基因腺瘤肠息肉基因(APC)可以促进侵袭性纤维瘤发生,AD-AM12、FAP、WISP1和SOX11基因在侵袭性纤维瘤中选择性高表达.
|
关 键 词: | 纤维瘤病,侵袭型 基因 |
Correlation of aggressive fibromatosis genes |
| |
Abstract: | Aggressive fibromatosis,also known as desmoid tumor,is a locally invasive soft tissue lesion arising from connective tissues.There is no metastasis to distant sites.The primary treatment remains surgical resection.It is characterized by high recurrence rates.The underlying mechanisms of development and regulation are unknown.Early detection is elusive.Recent studies have showed that mutations in either APC or β-catenin gene are probably a major driving force.And ADAM12,FAP,WISP1 and SOX11 are selectively over-expressed. |
| |
Keywords: | Fibromatosis,aggressive Genes |
本文献已被 万方数据 等数据库收录! |
|