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| 复方葛根注射液对血液流变学及血小板聚集功能的影响 | |
| 引用本文： | 张爱萍,曹伟建,余世春,陈琳,高署,李俊.复方葛根注射液对血液流变学及血小板聚集功能的影响[J].安徽医科大学学报,2004,39(4):273-275. |
| 作者姓名： | 张爱萍 曹伟建 余世春 陈琳 高署 李俊 |
| 作者单位： | 1. 安徽医科大学附属省立医院,合肥,230001 2. 安徽省安泰医药生物技术有限公司,合肥,230031 3. 安徽医科大学药学系,合肥,230032 |
| 摘 要： | 目的观察复方葛根注射液对大鼠血小板聚集功能及兔血液流变学的影响.方法 SD大鼠50只,随机分为正常组、试药组(20、40、80 mg/kg)及阳性药(川芎嗪40 mg/kg)组,测定给药3 d后血小板聚集率;家兔30只,随机分为正常组、试药组(10、20、40 mg/kg)及阳性药(川芎嗪20 mg/kg)组,测定给药3 d后血液流变学指标.结果复方葛根注射液能显著抑制血小板的聚集率;显著降低全血黏度、血浆黏度、红细胞压积及纤维蛋白原.结论复方葛根注射液对血液流变学有改善作用. |
| 关 键 词： | 葛根素/药理学 血小板聚集/药物作用 血液流变学/药物作用 |
| 文章编号： | 1000-1492(2004)04-0273-03 |
| 修稿时间： | 2003年11月5日 |
Effects of puerarin lobata injection on platelet aggregation and hemorrheology |
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| Zhang Aiping,Cao Weijian,Yu Shichunet al.Effects of puerarin lobata injection on platelet aggregation and hemorrheology[J].Acta Universitis Medicinalis Anhui,2004,39(4):273-275. | |
| Authors: | Zhang Aiping Cao Weijian Yu Shichun |
| Abstract: | Objective To observe platelet aggregation and hemorrheology after puerarin lobata injection. Methods 50 Sprague-Dawley rats were randomly divided into 5 groups with 10 in each: normal control group, ligustrazine (40 mg/kg) group, and three dose groups of puerarin lobata injection(20,40,80 mg/kg), then the platelet aggregation were detected 3 d after administering. 30 Sprague-Dawley rats were randomly divided into 5 groups with 6 in each: normal control group, the ligustrazine (20 mg/kg) group, and the three dose groups of puerarin lobata injection(10,20,40 mg/kg), then the hemorrheology were detected 3 d after administration. Results The different doses of Puerarin Lobata injection significantly inhibited platelet aggregation, decreased total blood viscosity, plasma viscosity, hematorit and fibrinogen. Conclusion The puerarin lobata injection can improve hemodynamics. |
| Keywords: | puerarin/pharmacology platelet aggregation/drug effects hemorrheology/drug effects |
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