探讨血VEGF、PAPP-A、D-D和尿NAG/Cr对妊娠高血压综合征的临床意义

目的探讨妊娠高血压综合征(PIH)患者血管内皮生长因子(VEGF)、血清妊娠相关血浆蛋白-A(PAPP-A)、D-二聚体(D-D)和N-乙酰-β-D-氨基葡萄糖甙酶/肌酐(NAG/Cr)比值的变化及意义。方法通过检测92例PIH患者和35例健康妊娠孕妇PAPP-A、VEGF、D-D和NAG/Cr的水平,分析其与PIH的关系。结果妊娠高血压综合征患者VEGF水平显著低于健康对照组,差异有统计学意义(P0.01),且随着病情的加重而显著降低,而PAPP-A、D-D、NAG/Cr水平显著高于健康对照组,差异有统计学意义(P0.01);且随着病情加重PAPP-A、D-D、NAG/Cr水平显著增高。结论 VEGF、PAPP-A、D-D、NAG/Cr与PIH的发生、发展密切相关,动态监测其水平变化对于PIH患者的病情判断、临床治疗均有重要意义。

Study the significance of blood VEGF,PAPP-A,D-D and urinary NAG/Cr ratio in patients with PIH

Objective To study the clinical significance of changes of blood contents of vascular endothelial growth factors (VEGF).Pregnancy-associated plasma protein-A(PAPP-A),D-dimers(D-D)and Urinary N-acetyl-β-D-glucosaminidase/Creatinine (NAG/Cr)Ratio in patients with Pregnancy Induced Hypertension syndrome(PIH).Methods Serum VEGF and PAPP-A(with ELISA),plasma D-dimers(with biochemistry)and NAG/Cr(with velocity)contents were measured in 92 pregnant women with PIH and 35 controls.Results The serum VEGF contents in patients with PIH were significantly lower than those in controls(P<0.01)while PAPP-A,D-dimers and NAG/Cr contents were significantly higher(P<0.01).Those changes were especially marked in patients with advanced diseases.Conclusion Changes of blood contents of VEGF,PAPP-A D-dimers and Urinary NAG/Cr Ratio were closely related with the disease process of PIH.Determination of these changes was of clinical diagnostic as well as prognostic value.