卡介菌多糖核酸预防生殖器疱疹复发的效果观察

目的：探讨肌内注射卡介菌多糖核酸（斯奇康）预防频繁复发的生殖器疱疹的效果。方法：选择无卡介菌多糖核酸（斯奇康）肌内注射禁忌证的频繁复发的生殖器疱疹患者（每年复发次数6次以上）86例，分成3组（A，B，C），分别给予卡介菌多糖核酸（斯奇康）联合阿昔洛韦片、单独阿昔洛韦片抑制疗法和单独肌内注射卡介菌多糖核酸（斯奇康）疗法。疗程均为1年，期间定期复诊，记录患者的生殖器疱疹复发情况及药物不良反应情况。结果：各组患者预防性治疗前的平均复发频率为9—10次／年，经过1年的连续性预防后，年均复发频率分别减少了80％，66％，22％。结论：卡介菌多糖核酸（斯奇康）肌内注射预防复发的生殖器疱疹有效，可以明显减少其复发频率。

Observation on efficacy of BCG-PSN on prevention of genital herpes recurrence

Objective To discuss the effect of intramuscular injection of polysaccharide nucleic acid fraction of bacillus calmette guerin(BCG-PSN) on the prevention of recurrence of genital herpes.Method Eighty-six patients with recurrent genital herpes(relapse more than six times per year) without intramuscular injection contraindication of BCG-PSN,were divided into 3 groups(group A,B,C),and respectively dispensed BCG-PSN plus Acyclovir,Acyclovir suppression therapy only,and intramuscular injection of BCG-PSN only.The period of treatment was 1 year with regular follow-up visits during the time.The recurrence of genital herpes patients and adverse drug reactions were recorded.Results The average recurrence frequency of all patients before preventive treatment was 9~10 times per year.After one year of continuous prevention,the annual recurrence rate was reduced by 80%,66% and 22%.Conclusion Intramuscular injection of BCG-PSN is effective on prevention of recurrence of genital herpes,and it can significantly reduce the recurrence.