3 D1HMRSI对外周带前列腺癌的鉴别诊断价值

目的应用3D1HMRSI(3D MRSI)研究外周带前列腺癌(PCa)的代谢特点,并初步探讨3DMRSI对外周带PCa的鉴别诊断价值方法分析18例良性前列腺增生(BPH)和21例PCa的3D MRSI表现测量外周带PCa体素及BPH外周带体素的(Cho Cre)/Cit及Cho/Cre,并分别比较PCa体素及BPH体素2组代谢物比值结果BPH的外周带波谱主要表现为Cit高耸,Cho次之,Cre最低,PCa波谱主要表现为Cit峰明显下降甚至消失,Cho显著升高,两者波峰可呈现倒置;PCa体素的(Cho Cre)/Cit显著高于BPH体素,两者仅存在小部分重叠,PCa体素的Cho/Cre也显著高于BPH体素,但两者存在较大部分重叠结论外周带PCa的3D MRSI表现具有特征性,(Cho Cre)/Cit是诊断外周带PCa的有效指标

The Value of Three-Dimensional Proton MR Spectroscopic Imaging in the Differential Diagnosis of Prostate Cancer in Peripheral Zone

Objective To study the metabolic characteristic of prostate cancer(PCa) in peripheral zone (PZ) with three-dimensional proton MR spectroscopic imaging (3D MRSI),and to evaluate the value of 3D MRSI in the differential diagnosis of prostate cancer in PZ. Methods 3D MRSI findings were reviewed in 18 benign prostatic hyperplasia (BPH) cases and 21 PCa cases.(Cho Cre)/Cit and Cho/Cre ratios of PCa and PZ of BPH were retrospectively measured,(Cho Cre)/Cit and Cho/Cre of PCa voxels were compared with BPH voxels. Results PZ of BPH showed dominant Cit,which was markedly higher than Cho and Cre. Significantly higher choline levels and lower citrate levels were observed in PCa compared with that of BPH. It showed statistically significant difference between (Cho Cre)/Cit ratios of PCa voxels and BPH voxels,PCa voxels had minimal overlap with BPH voxels. It also showed statistically significant differences between Cho/Cre ratio of PCa voxels and BPH voxels,but there was some overlap between two groups. Conclusion 3D MRSI can be successfully applied to the diagnosis of cancer in the PZ on the basis of the elevation of Cho and the reduction Cit in cancerous tissue compared with that of PZ tissue of BPH.