| 苦丁茶对豚鼠离体气管平滑肌收缩功能的影响 |
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| 引用本文： | 蒋建敏,许实波,江润祥.苦丁茶对豚鼠离体气管平滑肌收缩功能的影响[J].中国中药杂志,2001,26(12):853-856. |
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| 作者姓名： | 蒋建敏 许实波 江润祥 |
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| 作者单位： | 1. 中山大学生命科学学院药学系,
2. 香港中文大学中医学院, |
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| 基金项目： | 香港工业署工业发展科技基金项目(AF/323/97) |
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| 摘 要： | 目的 :研究苦丁茶对豚鼠离体气管平滑肌的影响。方法 :以累积技术建立CaCl2 和组织胺 (His)的量效曲线 ,研究了苦丁茶对CaCl2 ,His和乙酰胆碱 (Ach)等致喘介质对豚鼠离体气管平滑肌收缩功能的影响。结果 :CaCl2 和His引起气管条明显的收缩 ,pD2 分别为 3.59和 5 .34。苦丁茶能明显压低CaCl2 和His的量效曲线 ,并使曲线右移。苦丁茶对Ach和His 3×10-6mmol·L-1引起的气管平滑肌收缩有明显的逆转作用 ,IC50 分别为 0.16mg·ml-1和 0.2 1mg·ml-1。结论 :提示苦丁茶有明显的舒张豚鼠离体气管平滑肌的作用。
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| 关 键 词： | 苦丁茶 氯化钙 组织胺 乙酰胆碱 |
| 文章编号： | 1001-5302(2001)12-0853-04 |
| 收稿时间： | 2000/8/16 0:00:00 |
| 修稿时间： | 2000年8月16日 |
The Effect of Kudingcha (Ilex latifolia Thunb.) on the Contraction of Isolated Guinea-pig Tracheal Smooth Muscle in Vitro |
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| JIANG Jian min ;XU Shi bo ;KONG Yun cheung.The Effect of Kudingcha (Ilex latifolia Thunb.) on the Contraction of Isolated Guinea-pig Tracheal Smooth Muscle in Vitro[J].China Journal of Chinese Materia Medica,2001,26(12):853-856. |
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| Authors: | JIANG Jian min ;XU Shi bo ;KONG Yun cheung |
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| Institution: | Department of Pharmacy, Sun Yat-Sen University, Guangzhou 510275, Guangdong, China. |
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| Abstract: | Objective: To study the effects of Kudingcha ( Ilex latifolia Thunb., IL) on the isolated guinea pig tracheal smooth muscle in vitro. Method: By obtaining CaCl2 and Histamine accumulative dose response curves, to observe the influences of IL on the contraction of tracheal strips induced by calcium and some asthmogenic mediators. Result: CaCl2 and histamine caused significant contraction of tracheal smooth muscle and pD 2 was 3.55 and 5.34 respectively. After incubated with IL, the dose response curves of CaCl2 and histamine were significantly shifted to the right, and the maximal contractile force was reduced. IL could also inhibit isolated tracheal strip contraction induced by acetylcholine 3×10 -6 mol·L-1 and histamine 3×10-6 mol·L -1 , and IC50 was 0.16mg·ml-1 and 0.21mg·ml-1 . Conclusion: Kudingcha has significant dilated effects on tracheal smooth muscle. |
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| Keywords: | Kudingcha CaCl histamine acetylcholine |
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