Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia |
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Authors: | Iwayama-Shigeno Yoshimi Yamada Kazuo Itokawa Masanari Toyota Tomoko Meerabux Joanne M A Minabe Yoshio Mori Norio Inada Toshio Yoshikawa Takeo |
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Institution: | Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan. |
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Abstract: | Dysfunction of the N-methyl-D-aspartate (NMDA) type glutamate receptor has been proposed as a mechanism in the etiology of schizophrenia. Recently, we identified a variable (GT)n repeat in the promoter region of the NMDA NR2A subunit gene (GRIN2A), and showed its association with schizophrenia in a case-control study, together with a correlation between the length of the repeat and severity of chronic outcome. In this study, we extended our analyses, by increasing the number of case-control samples to a total of 672 schizophrenics and 686 controls, and excluded potential sample stratification effects. We confirmed the significant allelic association between the repeat polymorphism and disease (P = 0.011), and as in the previous study, we observed an over-representation of longer alleles in schizophrenia. These results suggest a probable genetic effect for the GRIN2A promoter (GT)n variation on the predisposition to schizophrenia in Japanese cohorts. |
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