冠状动脉CT血管成像定量参数与老年冠心病患者病情严重程度的相关性

目的探讨冠状动脉CT血管成像定量参数与老年冠心病患者病情严重程度的相关性。方法回顾性分析在我院治疗的老年冠心病患者150例为观察组,同时收集健康志愿者150例为对照组,行冠状动脉CT血管成像检查,获取斑块及血管体积、斑块负荷、血管狭窄、血管重建等定量参数,分析定量参数与冠心病患者病情严重程度的相关性。结果与对照组比较,观察组斑块数(2.43±0.53)个vs(0.82±0.32)个,P=0.000]、非钙化斑块体积(321.84±124.92)mm^3 vs(125.83±43.28)mm^3,P=0.000]、钙化斑块体积(43.28±12.84)mm^3 vs(12.74±4.39)mm^3,P=0.000]、总斑块体积(365.12±109.85)mm^3 vs(138.57±40.92)mm^3,P=0.000]和重建指数(1.89±0.43 vs 1.12±0.24,P=0.000)等均显著增高。Pearson线性相关分析显示,斑块数、非钙化斑块体积、钙化斑块体积、总斑块体积、非钙化斑块负荷、钙化斑块负荷、总斑块负荷、血管狭窄程度与LVEF呈负相关(P<0.01),与平均室壁应力、左心室质量指数、左心室收缩末期容积、左心室舒张末期容积呈正相关(P<0.05,P<0.01)。结论冠状动脉CT血管成像定量参数与老年冠心病患者病情严重程度相关,可用于评估患者预后。

Relationship between quantitative parameters of coronary CTA and severity of CHD in the elderly

Objective To study the relationship between quantitative parameters of coronary CTA and severity of CHD in the elderly.Methods One hundred and fifty elderly CHD patients admitted to our hospital served as an observation group and 150 healthy volunteers served as a control group.Their quantitative parameters of coronary CTA(plaques,vascular volume,plaque load,vascular stenosis and vascular remodeling)were recorded.The relationship between the quantitative parameters of coronary CTA and the severity of CHD were analyzed.Results The number of plaques was significanyly greater,the volume of non-calcified plaques,calcified plaques and total plaques was significantly larger,the revascularization index was significantly higher in observation group than in control group(2.43±0.53 vs 0.82±0.32,P=0.000;321.84±124.92 mm^3 vs 125.83±43.28 mm^3,P=0.000;43.28±12.84 mm^3 vs 12.74±4.39 mm^3,P=0.000;365.12±109.85 mm^3 vs 138.57±40.92 mm^3,P=0.000;1.89±0.43 vs 1.12±0.24,P=0.000).Pearson linear correlation analysis showed that the number of plaques,the volume of non-calcified plaques,calcified plaques and total plaques,the load of non-calcified plaques,calcified plaques and total plaques,and the severity of vascular stenosis were negatively related with the LVEF and positively related with the mean wall stress,LVMI,LVESV and LVEDV in the elderly(P<0.05,P<0.01).Conclusion The quantitative parameters of coronary CTA are closely related with the severity of CHD in the elderly and can thus be used in assessing their outcome.