脑深部电刺激术对帕金森病中轴症状影响的研究进展

原发性帕金森病以运动迟缓、静止性震颤及肌强直等运动症状为主要临床表现,随着疾病的进展常常出现姿势异常、平衡障碍及步态障碍等中轴症状。近年来PD治疗理念不断发展,无论是药物治疗还是非药物治疗,对于改善患者的运动症状已取得了显著的进步。DBS对PD患者中轴症状的治疗逐渐成为研究热点之一,然而由于PD中轴症状的复杂机制,DBS对其治疗效果仍存在争议。本文将总结近年来有关脑深部电刺激术对帕金森患者中轴症状作用的研究进展,希望能对帕金森病中轴症状的相关研究提供参考。

Advances in the effects of deep brain stimulation on axial symptoms of Parkinson's disease

Parkinson's disease（PD） is characterized by a combination of motor symptoms （bradykinesia, rest tremor,rigidity etc.） and non-motor symptoms（depression, anxiety etc.）. As the PD progresses, paitents may exhibit axial symptoms（including postural instability, balance disorder and gait disability）. Currently,both medication therapy and non-medication therapy make great progress in relieving the motor symptoms of PD. Therapy of deep brain stimulation on axial symptoms becomes one of the research hotspots. However,its effects remain controversial due to the complexity of the mechanism. In this paper, we summarize the development of researches on the effect of DBS on axial symptoms and provide reference for related studies.