血管肌纤维母细胞瘤与侵袭性血管粘液瘤临床病理分析

目的：探讨血管肌纤维母细胞瘤（ＡＭＦＢ）的临床病理特点及与侵袭性血管粘液瘤（ＡＡ）的鉴别。方法：对５例ＡＭＦＢ和５例ＡＡ进行临床病理和免疫组化研究，对３例ＡＭＦＢ进行电镜观察。结果：ＡＭＦＢ位于外阴或腹股沟我，肿瘤边界清楚，大小０．８～４ｃｍ。光镜：肿瘤细胞呈梭形上皮样、束头及巢状排列，常围绕小至中等大小的薄壁血管周围。肿瘤有细胞密集区和细胞分散区。免疫组化：肿瘤细胞表达ｖｉｍｅｎｔｉｎ，ｄｅｓｍ

Clinicopathologic analysis of angiomyofibroblastoma with comparison to aggres-sive angiomyxoma

Purpose To explore the c1inicopatho1ogic features of angiomyofibroblastoma and the relationship between angiomyofibroblastoma (AMFB) and aggressive angiomyxoma(AA) Methods Five cases of AMFB and 5 cases of AA were reviewed Conventional histologic and immunohistochemical features of AMFBs were compared with those of AAs Results The lesions of AMFB were located in the superficial vulvar regional and inguinal areas The tumors were well delineated and ranged in size from 0 8 to 4 cm in dimension Microscopically, they were composed of spindled and epithelioid cells arranged in cords and nests preferentially arrayed around numerous small to medium sized, thin walled vessels with some hyalined thick walls Four cases manifested zone of both dense and sparse cellularity Immunohistochemically, the tumor cells were strongly positive for vimentin, desmin, estrogen receptor and progesterone receptor None of the two cases with follow up of up to 2 years after simple excision developed a recurrence, in contract to AA that exhibited local recurrence in 2 of 5 cases Ultrastructurally, AMFB tumor cells contained some microfilaments and dense bodies Intercellular junctions were apparent Intercellular spaces contained a great of collagen fibers AA showed more indented nuclear, dense myxoid background and thick walled vessels Myoid bundles tended to be located adjacent to blood vessels in all cases Conclusion These results indicate that conventional morphologic analysis is paramount in the recognition of AMFB AMFB and AA shows different clinicopathologic entity and proposes an origin from a perivascular stem cel1 that is capable of myofibroblastic differentiation