| 妊高征血浆环核苷酸含量的变化 |
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| 引用本文： | 张凌云,赵艳辉,张为远. 妊高征血浆环核苷酸含量的变化[J]. 吉林大学学报(医学版), 2000, 26(6): 607-609 |
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| 作者姓名： | 张凌云 赵艳辉 张为远 |
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| 作者单位： | 第二临床学院妇产科 吉林 长春130041 |
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| 摘 要： | 目的 :探讨血浆环核苷酸在妊高征中的变化以及作用。方法 :采用竞争性蛋白结合分析的方法及其放射免疫方法测定 2 5例重度妊高征和 2 7例正常妊娠晚期妇女 (对照组 )血浆中环磷酸腺苷 (c AMP)和环磷酸鸟苷 (c GMP)的含量。结果 :妊高征患者血浆 c AMP和 c GMP的浓度远远高于正常对照组 ,并且妊高征产后组明显低于产前组。产前 c AMP与产后平均动脉压 (MAP)之间呈明显的负相关。结论 :c AMP和 c GMP在妊高征中表现出相互协同的作用 ,共同拮抗细胞内 Ca2 +升高引发的血管收缩
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| 关 键 词： | 妊高征 血浆 环磷酸腺苷 环磷酸鸟苷 Ca~(2+) |
| 文章编号： | 0253-3707(2000)06-0607-03 |
| 修稿时间： | 1999-12-22 |
Changes of plasma calcitonin gene-related peptide and endothelin levels in patients with pregnancy-induced hypertension |
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| Zhao Yanhui,Zhang Lingyun,Zhang Weiyuan. Changes of plasma calcitonin gene-related peptide and endothelin levels in patients with pregnancy-induced hypertension[J]. Journal of Jilin University: Med Ed, 2000, 26(6): 607-609 |
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| Authors: | Zhao Yanhui Zhang Lingyun Zhang Weiyuan |
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| Abstract: | ? Objective:To evaluate the effect of the plasma cyclic nucleotide in patients with pregnancyinduced hypertension.Methods:To observe the level of the plasma cAMP by radio competitive protein binding assay and level of the plasma cGMP by radioimmunoassay (RIA).Results:The contents of the plasma cAMP and cGMP were significantly higher in PIH group than those in the controls.Plasma cAMP showed the negative correlation to postpartum MAP.Conclusion:cAMP and cGMP had synergy on antagonizing the contraction evoked by Ca 2+ .This was an effective compensatory protective mechanism of PIH. |
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| Keywords: | pregnancy-induced hypertension plasma cAMP cGMP |
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