儿童川崎病丙种球蛋白治疗前后血清25-羟维生素D3及白介素6水平的变化及意义

目的通过检测川崎病（KD）患儿丙种球蛋白治疗前后血清25-羟维生素D3[（25-（OH）D3）]及白介素6（IL-6）水平，探讨其
与川崎病的关系。方法选取在我院住院的KD患儿35例，检测丙种球蛋白治疗前后血清25-（OH）D3和IL-6水平，并选取25例
呼吸道感染发热患儿作为发热对照组，25例正常儿童作为正常对照组，分别检测其血清25-（OH）D3和IL-6值，并对各组进行比
较。结果KD治疗前25-（OH）D3水平：正常儿童较发热儿童高（P=0.025）；KD患儿较正常儿童高（P=0.023），均有统计学意义；
血清IL-6水平：发热儿童虽较正常儿童高（P=0.4），但差异无统计学意义，KD患儿较发热儿童高（P=0.000），差异有统计学意义；
将25-（OH）D3与IL-6 水平进行相关分析，r=0.9，P=0.000。血清25-（OH）D3水平在丙种球蛋白治疗后较治疗前明显升高（P=
0.012），差异有统计学意义；血清IL-6水平在丙种球蛋白治疗后较治疗前降低（P=0.325），但差异无统计学意义；治疗后血清25-
（OH）D3与IL-6 水平无相关性（r=0.18，P=0.4）。结论KD 患儿治疗前血清25-（OH）D3与IL-6 水平呈正相关，治疗后无明显相
关。25-（OH）D3可能参与KD的发病，可作为KD的潜在治疗靶点。

Changes of serum 25-hydroxyvitamin D3 and interleukin-6 after treatment with intravenous immunoglobulins in children with Kawasaki disease

Objective To explore the changes of serum 25-hydroxyvitamin D3 [25-(OH)D3] and interleukin-6 (IL-6) in children
with Kawasaki disease (KD) after treatment with intravenous immunoglobulins (IVIG) and analyze their clinical implications.
Methods Thirty-five children with KD (26 boys and 9 girls) were examined for serum 25-(OH)D3 and IL-6 levels before and
after IVIG treatment using enzyme linked immunosorbent assay (ELISA), with 25 febrile children with respiratory tract
infections and 25 healthy children as controls. Results Serum 25-(OH)D3 levels were significantly higher in healthy children
than in febrile children (P=0.025), and was even higher in children with KD before IVIG treatment (P=0.023). Serum IL-6 levels
were similar between healthy and febrile children (P=0.4), but significantly elevated in KD children (P=0.000). Serum 25-(OH)
D3 level was positive correlated with serum IL-6 level in KD children before treatment (r=0.9, P=0.000). In KD children after
IVIG treatment, serum 25-(OH)D3 level was significantly increased (P=0.012) and serum IL-6 levels slightly decreased (P=0.325)
without showing any correlations (r=0.18, P=0.4). Conclusion Serum 25-(OH)D3 level is positively correlated with serum IL-6
level in KD children before IVIG treatment but not after the treatment,. 25(OH)D3 may participate in the pathogenesis of KD
and potentially serves as the therapeutic target for KD.