| Neoadjuvant chemotherapy for triple-negative breast cancer: a meta-analysis with 7168 cases简 |
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| 基金项目： | grants,from,the,Liaoning,Province,Science&Technol-ogy,Development,Funds(项目编号：2012225019)the,Sub-topics,of,Major,Drug,Discovery,Platform,in,the,Twelfth-Five,Year,Research,of,China(项目编号：2012ZX09303016-002) |
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| 摘 要： |
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Neoadjuvant chemotherapy for triple-negative breast cancer:a meta-analysis with 7168 cases |
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| Authors: | Guojing Zhang Wanqing Xie Co-first author Chao Lin Zhaozhe Liu Long Xu Guanzhong Zhang Fang Guo Yaling Han Hongxin Zheng Xiaodong Xie |
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| Institution: | Guojing Zhang(Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China)；Wanqing Xie Co-first author(Molecular Biology Laboratory of Traditional Chinese Medicine, The Basic Medical College of Liaoning University of Traditional Chinese Medicine, Shengyang 110032, China)；Chao Lin(Department of Gynaecology and 0bstetrics, Zhejiang Chinese Medical University Affiliated Hospital of Wenzhou Traditional Chinese Medicine, Wenzhou 325000, China)；Zhaozhe Liu(Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China)；Long Xu(Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China)；Guanzhong Zhang(Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China)；Fang Guo(Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China)；Yaling Han(Cardiovascular Disease Institute, General Hospital of Shenyang Military Region, Shenyang 110840, China)；Hongxin Zheng(Molecular Biology Laboratory of Traditional Chinese Medicine, The Basic Medical College of Liaoning University of Traditional Chinese Medicine, Shengyang 110032, China)；Xiaodong Xie(Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China)； |
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| Abstract: | Objective:The pathological complete response (pCR) rates of neoadjuvant chemotherapy (NAC) in triple-nega-tive breast cancer (TNBC) was reported higher than that in non-TNBC but ranged from 12%to 48%. pCR was reported to be a predictor of long overal survival and exact pCR rate of NAC in TNBC would give us some hints on how to improve outcomes of TNBC patients. The meta-analysis was conducted to estimate the pCR rate of NAC for TNBC through contrasting the pCR rates of TNBC and non-TNBC tumors in NAC. Methods:Studies were selected from the PubMed database and Cochrane Col aboration Library. pCR rates were col ected in groups of TNBC and non-TNBC tumors. Review Manager 4.2 was used to perform forest plots and funnel plots. Results:The analysis included 22 studies with 7168 patients, the aggregate pCR rate was 29.5%in TNBC group, which was 17.7%higher than non-TNBC. The summary relative risk (RR) for pCR rate of TNBC group with that of non-TNBC group was 2.55. No obvious statistical heterogeneity and publication bias was detected. Conclu-sion:This meta-analysis demonstrated that NAC showed a higher pCR rate in TNBC than non-TNBC. |
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