|
|||||
|
|
MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer |
|
| Authors: | Li Chenglong Nie Hui Wang Ming Su Liping Li Jianfang Yu Beiqin Wei Min Ju Jingfang Yu Yingyan Yan Min Gu Qinlong Zhu Zhenggang Liu Bingya |
| Institution: | a Laboratory of Molecular Oncology, Department of Urology, Yamagata University School of Medicine, Iida-nishi 2-2-2, Yamagata 990-9585, Japan b Department of Human Pathology (Second Department of Pathology), Yamagata University School of Medicine, Iida-nishi 2-2-2, Yamagata 990-9585, Japan c Tumor Biology Core, Center for Developmental Therapeutics, Chemistry of Life Processes Institute, Silverman Hall B733, Northwestern University, Evanston, IL |
| Abstract: | Recently, we have identified GSK-3 as a new therapeutic target in renal cell cancer (RCC). miR-199a could potentially downregulate GSK-3β expression. Here, we found a decreased miR-199a expression in 59% (32 of 54) of RCCs and it was correlated with higher tumor stage (p < 0.05) and nuclear overexpression of GSK-3β (p < 0.05). We show that re-expression of miR-199a downregulates GSK-3β and suppresses cancer cell growth. Our results demonstrate low miR-199a expression as a feature of advanced RCCs, identify miR-199a as a negative regulator of GSK-3β, and suggest re-expression of pre-miR-199a as a new potential treatment of RCC. |
| Keywords: | Renal cell carcinoma miR-199 Glycogen synthase kinase-3β Apoptosis Targeted therapy |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |