Redox-regulating role of insulin: the essence of insulin effect期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Redox-regulating role of insulin: the essence of insulin effect

Authors:	Wang Xin Tao Ling Hai Chun X

Affiliation:	^a Department of Toxicology, School of Preventive Medicine, The Fourth Military Medical University, Xi’an 710032, China ^b Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China

Abstract:

Keywords:	4-HNE, 4-hydroxynonenal 8-OHdG, 8-hydroxydeoxyguanosine 8-OHG, 8-hydroxyguanine 8-iso-PGF_2α, 8-iso-prostaglandin F_2α AD, Alzheimer&rsquo s disease AIDS, acquired immunodeficiency syndrome Akt, protein kinase B AMI, acute myocardial infarction APS, adaptor protein with pleckstrin homology and src homology 2 domains ARE, antioxidant responsive element CAP, Cbl/Cbl-associated protein CAT, catalase Cbl, Cbl family of adapters, which comprises c-Cbl, Cbl-b, and Cbl-c/Cbl-3, is implicated in receptor tyrosine kinase signaling CoQ, coenzyme Q CuZnSOD, copper and zinc SOD DCM, dilated cardiomyopathy DM, diabetes mellitus ERK, extracellular signal-regulated kinases Fln, flotillin G-6-P, glucose-6-phosphate G6PD, glucose-6-phosphate dehydrogenase GCL, γ-glutamylcysteine ligase GCLc, catalytic subunit of γ-glutamylcysteine ligase GCLm, modulatory subunit of γ-glutamylcysteine ligase GIK, glucose, insulin, and potassium GPG, G-phosphogluconate GPx, glutathione peroxidase GR, glutathione reductase Grb2, growth factor receptor binding protein 2 GSH, glutathione GSK-3, glycogen synthase kinase 3 GSSG, GSH disulfide GST, glutathione-S-transferases H₂O₂, hydrogen peroxide HO-1, heme oxygenase-1 IGF-1, Insulin-like growth factor 1 IGF-1R, insulin growth factor-1 receptor IR, insulin receptor IRS1, insulin receptor substrate 1 IRS2, insulin receptor substrate 2 JNK, Jun N-terminal kinase Keap1, Kelch-like ECH-associated protein 1 LPO, lipid peroxidation MAPK, mitogen-activated protein kinase MEK, mitogen-activated protein kinase kinase MDA, malondialdehyde MIMP, mitochondrial inner membrane potential MnSOD, manganese SOD MPO, myeloperoxidase mTOR, mammalian target of rapamycin NF-κB, nuclear factor κB NADP⁺, oxidized nicotinamide-adenine dinucleotide phosphate NADPH, nicotinamide adenine dinucleotide phosphate NQO1, NAD(P)H quinone oxidoreductase 1 NO, nitric oxide NOS, nitric oxide synthase Nrf2, nuclear factor erythroid 2-related factor 2 NTY, nitrotyrosine O₂ 0" alt=" radical dot" src=" http://cdn.els-cdn.com/sd/entities/rad" class=" glyphImg" >^&minus , superoxide 0" alt=" radical dot" src=" http://cdn.els-cdn.com/sd/entities/rad" class=" glyphImg" >OH, hydroxyl ONOO 0" alt=" radical dot" src=" http://cdn.els-cdn.com/sd/entities/rad" class=" glyphImg" >, peroxynitrite P70S6K, ribosomal p70 S6 kinase PCIs, percutaneous coronary interventions PDK1, phosphoinositide-dependent kinase-1 PI3K, phosphatidylinositol 3&prime -kinase PKC, protein kinase C Prx, peroxiredoxin RAF, v-raf-1 murine leukemia viral oncogene homolog 1, raf proto-oncogene serine/threonine protein kinase Ras, a small GTP binding protein RO 0" alt=" radical dot" src=" http://cdn.els-cdn.com/sd/entities/rad" class=" glyphImg" >, alkoxyl RNS, reactive nitrogen species ROS, reactive oxygen species ROO 0" alt=" radical dot" src=" http://cdn.els-cdn.com/sd/entities/rad" class=" glyphImg" >, peroxyl RS 0" alt=" radical dot" src=" http://cdn.els-cdn.com/sd/entities/rad" class=" glyphImg" >, thiyl Shc, Src homology domain adaptor homolog family member SOD, superoxide dismutase STZ, streptozotocin SOS, mammalian son of sevenless T1DM, type 1 diabetes mellitus T2DM, type 2 diabetes mellitus TBARS, thiobarbituric acid reactive substances tBHP, tert-butylhydroperoxide tBHQ, tert-butylhydroquinone TPB-2, thioredoxin binding protein-2 TC10, Rho family member GTPase TRAP, total radical trapping antioxidant parameter Trx, thioredoxin Trx-S₂, oxidized form of Trx Trx-SH₂, reduced form of Trx TrxR, thioredoxin reductase TXNIP, thioredoxin-interacting protein UCP, uncoupling protein
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