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Vitamin D receptor gene polymorphism and its association with Parkinson's disease in Chinese Han population |
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| Authors: | Han Xun Xue Li Li Yongsheng Chen Biao Xie Anmu |
| Institution: | a Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, Shenyang 110001, China b Department of Pediatric Dentistry, School of Stomatology, China Medical University, Shenyang 110002, China c Molecular Therapeutics Research Group, School of Pharmacy, Queen's University, Northern Ireland, UK |
| Abstract: | Decreased cerebral blood flow causes cognitive impairments and neuronal injury in vascular dementia. In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils. Treatment with 5 mg/kg of donepezil for 21 consecutive days following a 10-min period of ischemia significantly inhibited delayed neuronal death in the hippocampal CA1 region. In Morris water maze test, memory impairment was significantly improved by donepezil treatment. Western blot analysis showed that donepezil treatment prevented reductions in p-CaMKII and p-CREB protein levels in the hippocampus. These results suggest that donepezil attenuates the memory deficit induced by transient global cerebral ischemia and this neuroprotection may be associated with the phosphorylation of CaMKII and CERB in the hippocampus. |
| Keywords: | Donepezil Global cerebral ischemia Neuroprotection Memory CAMK II CREB |
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