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Effects of overt and covert attention on the steady-state visual evoked potential |
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| Authors: | Walter Sabrina Quigley Cliodhna Andersen Søren K Mueller Matthias M |
| Affiliation: | a Department of Biomorphology and Biotechnologies, Division of Biology and Genetics, University of Messina, Italy b Institute of Psychiatry, University of Bologna, Bologna, Italy c Department of Psychiatry, College of Medicine, Korea University, Ansan, Kyounggi-Do, Republic of Korea d Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi-Do, Republic of Korea e Department of Neurology, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi-Do, Republic of Korea f Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA |
| Abstract: | The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. Two-hundred twenty one in-patients suffering from SKZ and 170 psychiatrically healthy controls were genotyped for 10 SNPs within CREB1, CREBBP and CREM. All patients were assessed for the severity of illness at baseline and at discharge by means of the Positive and Negative Symptoms Scale (PANSS). Our findings suggest the lack of influence of SNPs under investigation in the present study on the susceptibility to SKZ and on the response to antipsychotics. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions. |
| Keywords: | Schizophrenia CREB1 CREBBP CREM |
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