BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells |
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| Authors: | Otsuka Fumio Tsukamoto Naoko Miyoshi Tomoko Iwasaki Yasumasa Makino Hirofumi |
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| Affiliation: | a Endocrine Center of Okayama University Hospital and Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama 700-8558, Japan
b Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Nankoku 783-8505, Japan |
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| Abstract: | The existence of a functional bone morphogenetic protein (BMP) system in the pituitary has been recognized. Recent studies have provided evidence that BMPs elicit differential actions in the regulation of prolactin (PRL) and adrenocorticotropin (ACTH) release in lactotropinoma and corticotropinoma cells, respectively. BMPs play a key role in the modulation of somatostatin receptor (SSTR) sensitivity of lactosomatotrope cells in an autocrine/paracrine manner. In addition, SSTR action enhances BMP responsiveness in corticotrope cells. The functional link between BMP receptor signaling and SSTR actions may be crucial for individual tolerance to somatostatin analogs for controlling PRL and ACTH production. Adjustment of the endogenous SSTR sensitivity may be an effective strategy to inhibit the growth activity and hormonal productivity of intractable pituitary tumors. |
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| Keywords: | ActRI and ActRII, activin type I and type II receptors ALK, activin receptor-like kinase BMP, bone morphogenetic protein BRC, bromocriptine BMPRI and BMPRII, BMP type I and type II receptors DA, dopamine agonists D2R, dopamine D2 receptor FSK, forskolin GDF, growth differentiation factor GH, growth hormone POMC, proopiomelanocortin PRL, prolactin SSTR, somatostatin receptor TGF-β, transforming growth factor-β |
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