Transient bulging fontanelle after vaccination: case report and review of the vaccine adverse event reporting system |
| |
Authors: | Freedman Stephen B Reed John Burwen Dale R Wise Robert P Weiss Amy Ball Robert |
| |
Affiliation: | Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. |
| |
Abstract: | OBJECTIVE: To describe the features of transient bulging fontanelle (TBF) after vaccination. STUDY DESIGN: We searched the Vaccine Adverse Event Reporting System database for reports describing bulging fontanelle. We defined a definite TBF case as a patient with a bulging fontanelle, normal neuroimaging and cerebrospinal fluid analysis, and absence of a depressed level of consciousness, focal neurologic findings, or identified cause. Follow-up had to reveal normal development. Probable cases lacked either lumbar puncture or neuroimaging or both but met all other criteria. RESULTS: We identified 18 patients with definite or probable TBF. The median age at presentation was 4.5 months, interval from vaccination to symptom onset was 18 hours, and time to resolution was 3 days. Fifteen children were febrile. CONCLUSIONS: We cannot conclude that vaccines cause TBF. Further controlled studies are necessary. Even if further research verifies TBF as a rare side effect, immunization benefits would still vastly outweigh this hypothetical risk. However, confirmation of a vaccine association could modify the management of infants who develop TBF after immunizations. |
| |
Keywords: | COSTART, Coding symbols for thesaurus of adverse reaction terms DT, Diphtheria-tetanus vaccine DTP, Diphtheria- tetanus-(whole cell) pertussis vaccine (given separately or with HIB) DTaP, Diphtheria-tetanus-acellular pertussis vaccine HIB, Haemophilus influenzae type B conjugate vaccine PCV, Pneumococcal conjugate vaccine TBF, Transient bulging fontanelle VAERS, Vaccine Adverse Event Reporting System |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|