狗肝菜乙醇提取物的化学成分研究

目的:对狗肝菜Dicliptera chinensis全草的化学成分进行研究。方法:采用硅胶柱色谱和制备性薄层色谱及反相HPLC进行分离、纯化,UV,NMR和MS等方法进行结构鉴定。结果:从狗肝菜乙醇提取物的醋酸乙酯萃取部分得到7个化合物,分别鉴定为环八硫(1),开环异落叶松脂醇二甲醚二乙酸酯(2),5-甲氧基-4,4′-二氧甲基开环落叶松脂醇二乙酸酯(3),羟基华远志内酯甲醚(4),黑麦草内酯(5),β-谷甾醇葡萄糖苷(6),豆甾醇葡萄糖苷(7)。结论:除化合物6外,其他化合物皆为首次从该属植物中发现。

Studies on the chemical constituents in herbs of ethanolic extract from herbs of Dicliptera chinensis

OBJECTIVE: To study the chemical constituents of ethanolic extract from herbs of Dicliptera chinensis. METHOD: The compounds were separated by silica gel column chromatography, preparation TLC and reverse phase HPLC, their structures were identified by the spectroscopic methods of UV, NMR and MS. RESULT: Seven compounds were isolated from ethyl acetate extract. Their structure were identified as octasulphur (1), secoisolariciresinol dimethyl ether diacetate (2), 5-methoxy-4, 4'-di-O-methyl secolariciresinol (3), chinensinaphthol methyl ester (4), loliolide (5), beta-sitosterol 3-O-beta-D-glucopyranoside (6) and stigmasterol 3-O-beta-D-glucopyranoside (7). CONCLUSION: All the compounds except 6 were obtained from the plants of Dicliptera for the first time.