甘氨双唑钠放疗增敏治疗乳腺癌脑转移的疗效分析

【摘 要】目的 观察甘氨双唑钠放疗增敏在乳腺癌脑转移患者治疗中的疗效和毒副反应。方法 36例乳腺癌脑转移患者中16例行甘氨双唑钠增敏放疗，20例行单纯放疗。放疗方案：DT40 Gy／20次或30 Gy／10次。放疗增敏组甘氨双唑钠800 mg／m2，每周3次。比较两组近期疗效、颅内中位无进展生存期（PFS）及毒副反应。结果 甘氨双唑钠放疗增敏组的有效率为87.5％，单纯放疗组为50.0％，差异有统计学意义（P＜0.05）。放疗增敏组颅内中位PFS为9.9个月，单纯放疗组为5.3个月，差异有统计学意义（P＜0.05）。两组毒副反应主要为脱发、头痛、恶心呕吐和白细胞减少，均为1～2级，差异无统计学意义（P＞0.05）。结论 甘氨双唑钠放疗增敏治疗乳腺癌脑转移具有较好的疗效，且不增加毒副反应。

Curative effects on breast cancer with brain metastasis treated by sodium glycididazole in combination with radiotherapy

Objective To observe the efficacy and safety of sodium glycididazole（CMNa） in combination with radiotherapy on breast cancer with brain metastasis. Methods Thirty-six breast cancer patients with brain metastasis were enrolled in this study. Sixteen patients were treated with CMNa+radiotherapy（CMNa group），and 20 patients were treated with radiotherapy alone（radiation group）. The total dosage of radiation was 40 Gy／20 f，or 30 Gy／10 f. CMNa was taken 800 mg／m2 three times a week. The response rate（RR），median intracranial progression-free survival（PFS）and side effects were analyzed. Results The RR of CMNa group was 87.5％，and 50.0％ in radiation group，with significant differences（P＜0.05）. The median intracranial PFS of CMNa group was 9.9 months，and 5.3 months in radiation group，with significant differences（P＜0.05）.The main side effects of the two groups were hair loss，headache，nausea/vomitting and leukopenia of grade 1-2（P＞0.05）. Conclusion CMNa in combination with radiotherapy is a feasible and effective treatment for breast cancer with brain metastasis without increase in side effects.