Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus |
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Authors: | Bai Hui Chen;Joon Ha Park;Jeong Hwi Cho;In Hye Kim;Bich Na Shin;Ji Hyeon Ahn;Seok Joon Hwang;Bing Chun Yan;Hyun Jin Tae;Jae Chul Lee;Eun Joo Bae;Yun Lyul Lee;Jong Dai Kim;Moo-Ho Won;Il Jun Kang; |
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Institution: | Bai Hui Chen;Joon Ha Park;Jeong Hwi Cho;In Hye Kim;Bich Na Shin;Ji Hyeon Ahn;Seok Joon Hwang;Bing Chun Yan;Hyun Jin Tae;Jae Chul Lee;Eun Joo Bae;Yun Lyul Lee;Jong Dai Kim;Moo-Ho Won;Il Jun Kang;Department of Physiology, College of Medicine, and Institute of Neurodegeneration and Neuroregeneration, Hallym University;Department of Neurobiology, School of Medicine, Kangwon National University;Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University;Department of Integrative Traditional & Western Medicine, Medical College, Yangzhou University;Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University;Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University;Department of Food Science and Nutrition, Hallym University; |
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Abstract: | Oenanthe javanica is an aquatic perennial herb that belongs to the Oenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glutamate-induced neurotoxicity. However, few studies regarding effects of Oenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract of Oenanthe javanica on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67(an endogenous marker for cell proliferation) and doublecortin(a marker for neuroblast). Our results showed that Oenanthe javanica extract significantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was significantly increased in the dentate gyrus of the Oenanthe javanica extract-treated group compared with the control group. However, we did not find that vascular endothelial growth factor expression was increased in the Oenanthe javanica extract-treated group compared with the control group. These results indicate that Oenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-derived neurotrophic factor immunoreactivity in the rat dentate gyrus. |
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Keywords: | nerve regeneration Oenanthe javanica extract cell proliferation neuroblast differentiation brain-derived neurotrophic factor vascular endothelial growth factor rat neural regeneration |
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