Snail和E-cad在化生性乳腺癌中的表达及其临床意义

【摘 要】目的 探讨化生性乳腺癌组织中Snail和上皮性钙黏附素（E-cad）的表达水平及其与临床病理特征的关系。方法 采用免疫组化SP法检测58例化生性乳腺癌组织中Snail和E-cad的表达，并收集相应病例的临床病理资料，分析Snail、E-cad表达与化生性乳腺癌临床病理特征的关系及两蛋白的相关性，同时根据随访资料分析两者表达与复发转移的关系。 结果 在化生性乳腺癌中，Snail和E-cad的阳性表达率分别为77.6％（45／58）和483％（28／58）。Snail的表达与临床分期、淋巴结转移和ER表达有关（P＜0.05），而E-cad表达与组织学分级、淋巴结转移有关（P＜0.05），两者与年龄、HER-2表达、病理类型、肿瘤大小及月经状态均无关（P＞0.05）。Snail与E-cad的表达呈负相关（r=-0.308，P=0.019），且均与化生性乳腺癌复发转移有关（P＜0.05）。结论 Snail和E-cad联合检测可判断化生性乳腺癌的恶性程度和侵袭能力，且与复发转移有关，两者有望作为化生性乳腺癌治疗的分子靶点。

Expression and clinical significance of Snail and E-cad in metaplastic breast cancer

Objective To investigate the expression of Snail and E-cadherin（E-cad）in metaplastic breast cancer（MBC）tissues as well as their relationship with clinicopathological parameters. Methods The expression of Snail and E cad in 58 cases of MBC were detected by immunohistochemical SP method. The corresponding clinical data were collected and then the relationship of Snail，E-cad expression and the pathological parameters of MBC were analyzed. The relationship between the Snail，E-cad expression and recurrence／metastasis were analyzed according to the follow-up data. Results In these 58 MBC patients，Snail was expressed in 45 cases（77.6％）and E-cad was expressed in 28 cases（48.3％）. The expression of Snail was associated with clinical stage，lymph node metastasis and ER expression（P＜0.05）. The expression of E-cad was associated with histological grade and lymph node metastasis（P＜0.05）. The two proteins had no relationchip with age, tumor size, menopausal status, HER-2 expression and pathological types（P＞0.05）. The expression of Snail and E cadherin had a negative association （r=-0.308，P=0.019）. In MBC，both of them had relationship with local recurrence and distant metastasis（P＜0.05）. Conclusion Snail and E-cadherin may have the ability to recognize the tent of malignancy and invasion of MBC，which may be potential treatment target in MBC.