| 衰老动物模型的研究及其在抗衰老药物活性筛选中的应用 |
| |
| 引用本文： | 周玉枝,闫明亮,高丽,秦雪梅,杜冠华.衰老动物模型的研究及其在抗衰老药物活性筛选中的应用[J].中草药,2017,48(6):1061-1071. |
| |
| 作者姓名： | 周玉枝 闫明亮 高丽 秦雪梅 杜冠华 |
| |
| 作者单位： | 山西大学 中医药现代研究中心, 山西 太原 030006;山西大学 中医药现代研究中心, 山西 太原 030006;山西大学化学化工学院, 山西 太原 030006;山西大学 中医药现代研究中心, 山西 太原 030006;山西大学 中医药现代研究中心, 山西 太原 030006;山西大学 中医药现代研究中心, 山西 太原 030006;中国医学科学院 北京协和医科大学药物研究所, 北京 100050 |
| |
| 基金项目： | 国家自然科学基金资助项目（81673572）；山西省科技基础条件平台建设项目（2014091022）；山西省科技攻关项目（20140313008-14）；山西省应用基础研究项目（201601D021164）；山西省高校科技创新项目（2016120） |
| |
| 摘 要： | 衰老以及衰老相关疾病使得人类生活的负担逐年加重。延缓衰老、减少衰老相关疾病的发生是解决问题的根源。动物模型是衰老研究的重要工具,就酵母、线虫、果蝇、斑马鱼、快速老化小鼠、D-半乳糖衰老模型、恒河猴等多种衰老研究中常用动物模型的特点及其在抗衰老药物筛选中的应用进展进行归纳总结,为衰老研究中相关动物模型的选择提供依据。
|
| 关 键 词： | 衰老 动物模型 药物筛选 抗衰老 酵母 线虫 果蝇 斑马鱼 快速老化小鼠 D-半乳糖衰老模型 恒河猴 |
| 收稿时间： | 2016/10/18 0:00:00 |
Study on aging animal models and its application in activity screening of anti-aging drugs |
| |
| ZHOU Yu-zhi,YAN Ming-liang,GAO Li,QIN Xue-mei and DU Guan-hua.Study on aging animal models and its application in activity screening of anti-aging drugs[J].Chinese Traditional and Herbal Drugs,2017,48(6):1061-1071. |
| |
| Authors: | ZHOU Yu-zhi YAN Ming-liang GAO Li QIN Xue-mei and DU Guan-hua |
| |
| Institution: | Modern Research Center for Traditional Chinese Medicine, Shanxi University;Taiyuan 030006, China;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Taiyuan 030006, China;College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Taiyuan 030006, China;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Taiyuan 030006, China;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Taiyuan 030006, China;Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China |
| |
| Abstract: | Aging and aging-related diseases make human life burden increase year by year. We can solve this problem by delaying aging and reducing the incidence of aging-related diseases. Animal model is an important tool for aging research, in this paper, we focused on all kinds of models for aging study including Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, senescence accelerated mouse, D-galactose induced aging model, and rhesus. The characteristics, application status, and research progress of these models were introduced separately, which provides the basis for the selection of animal models in aging research. |
| |
| Keywords: | aging animal model drug screening anti-aging activity Saccharomyces cerevisiae Caenorhabditis elegans Drosophila melanogaster Danio rerio aenescence accelerated mouse D-galactose induced aging model rhesus |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
