| 海南狗牙花的生物碱化学成分研究 |
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| 引用本文： | 张东博,杨勇,宋忠兴,孙萌,李啟恩,唐志书. 海南狗牙花的生物碱化学成分研究[J]. 中草药, 2017, 48(7): 1286-1291 |
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| 作者姓名： | 张东博 杨勇 宋忠兴 孙萌 李啟恩 唐志书 |
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| 作者单位： | 陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083;陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083;陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083;兰州大学 功能有机分子化学国家重点实验室, 甘肃 兰州 730000;青海大学藏医学院, 青海 西宁 810001;陕西中医药大学/陕西省中药资源产业化协同创新中心/陕西省中药基础与新药研究重点实验室/陕西省风湿与肿瘤类中药制剂工程技术研究中心, 陕西 咸阳 712083 |
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| 基金项目： | 国家自然科学基金资助项目（81373978）；陕西省科技资源开放共享平台项目（2015FWPT-01）；陕西省重点科技创新团队（2012KCT-20） |
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| 摘 要： | 目的对海南狗牙花Ervatamia hainanensis的生物碱化学成分进行研究。方法采用硅胶、Sephadex LH-20、MCI以及半制备HPLC等色谱方法进行分离纯化,根据理化性质和现代波谱学技术鉴定化合物的结构。结果从海南狗牙花甲醇提取物中分离得到12个生物碱,分别鉴定为冠狗牙花碱(1)、19-表海尼山辣椒碱(2)、9,10-二甲氧基冠狗牙花碱(3)、老刺木碱(4)、老刺木碱-4-氮氧化物(5)、3-oxo-19-epi-heyneanine(6)、劲直胺(7)、deacetylakuammiline(8)、pandine(9)、rhazicine(10)、rhazicine N(4)-oxide(11)、rhazimine(12)。结论化合物8、10~12为首次从该属植物中分离得到,化合物3、5~7为首次从该植物中分离得到。
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| 关 键 词： | 夹竹桃科 狗牙花属 海南狗牙花 单萜吲哚生物碱 喹啉生物碱 9, 10-二甲氧基冠狗牙花碱 |
| 收稿时间： | 2016-09-21 |
Study on alkaloids from Ervatamia hainanensis |
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| ZHANG Dong-bo,YANG Yong,SONG Zhong-xing,SUN Meng,LI Qi-en and TANG Zhi-shu. Study on alkaloids from Ervatamia hainanensis[J]. Chinese Traditional and Herbal Drugs, 2017, 48(7): 1286-1291 |
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| Authors: | ZHANG Dong-bo YANG Yong SONG Zhong-xing SUN Meng LI Qi-en TANG Zhi-shu |
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| Affiliation: | Shaanxi University of Chinese Medicine/Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization/Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Xianyang 712083, China;Shaanxi University of Chinese Medicine/Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization/Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Xianyang 712083, China;Shaanxi University of Chinese Medicine/Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization/Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Xianyang 712083, China;State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;College of Tibetan Medicine, Qinghai University, Xining 810001, China;Shaanxi University of Chinese Medicine/Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization/Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research/Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Xianyang 712083, China |
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| Abstract: | Objective To study the alkaloids from Ervatamia hainanensis. Methods The alkaloids were isolated and purified by silica gel, MCI, Sephadex LH-20 column chromatography, and semi-preparative HPLC, and their structures were elucidated by physical and spectroscopic analysis. Results Twelve alkaloids were obtained and identified as coronaridine (1), 19-epi-heyneanine (2), 9,10-dimethoxycoronaridine (3), vobasine (4), vobasine N(4)-oxide (5), 3-oxo-19-epi-heyneanine (6), strictamine (7), deacetylakuammiline (8), pandine (9), rhazicine (10), rhazicine N(4)-oxide (11), and rhazimine (12). Conclusion Compounds 8 and 10-12 are isolated from the genus Ervatamia Stapf for the first time, while compounds 3 and 5-7 are firstly obtained from E. hainanensis. |
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| Keywords: | Apocynaceae Ervatamia Stapf Ervatamia hainanensis Tsiang monoterpenoid indole alkaloids quinoline alkaloids 9, 10-dimethoxycoronaridine |
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