| JNK信号通路与眼部胞外刺激的关系研究 |
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| 引用本文： | 李絮莹,王淑荣,梁家铭,汪倩,张妍. JNK信号通路与眼部胞外刺激的关系研究[J]. 国际眼科杂志, 2017, 17(5): 897-900. DOI: 10.3980/j.issn.1672-5123.2017.5.24 |
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| 作者姓名： | 李絮莹 王淑荣 梁家铭 汪倩 张妍 |
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| 作者单位： | 1. 130041 中国吉林省长春市,吉林大学第二医院眼科;130021中国吉林省长春市,吉林大学白求恩医学部;2. 吉林大学第二医院眼科, 中国吉林省长春市,130041 |
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| 基金项目： | 吉林大学白求恩支持计划(No.470110000520); 吉林大学优秀青年教师培养计划(No.419080500586) |
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| 摘 要： | JNK,即c-Jun氨基末端激酶,是丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)家族中一员.近些年有关它的研究一直相当活跃,它被发现与生物细胞增殖、凋亡、分化有着紧密联系,同时,许多疾病的发生也与它的活化密切相关.本文将通过详细阐述JNK信号通路与眼部结构所受各胞外刺激的关系,介绍最新研究进展,从而为治疗眼部疾病找到新的参考依据.
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| 关 键 词： | 信号通路 JNK 眼部 细胞凋亡 炎症 |
| 收稿时间： | 2016-11-28 |
| 修稿时间： | 2017-03-29 |
JNK signaling pathway and extracellular stimulations in ocular tissue |
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| Xu-Ying Li,Shu-Rong Wang,Jia-Ming Liang,Qian Wang and Yan Zhang. JNK signaling pathway and extracellular stimulations in ocular tissue[J]. International Eye Science, 2017, 17(5): 897-900. DOI: 10.3980/j.issn.1672-5123.2017.5.24 |
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| Authors: | Xu-Ying Li Shu-Rong Wang Jia-Ming Liang Qian Wang Yan Zhang |
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| Affiliation: | Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China; Norman Bethune Health Science Center of Jilin University, Changchun 130021, China;Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China;Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China; Norman Bethune Health Science Center of Jilin University, Changchun 130021, China;Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China;Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China |
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| Abstract: | JNK,which is called the c-Jun N-terminal kinase, is a member of mitogen activated protein kinases, located in cytoplasm. The studies on JNK have been quite active recently. It not only has close connections to cell generation, differentiation and apoptosis, but also plays a crucial role in numerous diseases. This paper expounds the relationship between JNK signaling pathway and extracellular stimuli in the eye structure, and introduces the latest achievement, so as to find the new references for therapy among eye diseases. |
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| Keywords: | signaling pathways JNK eye apoptosis inflammation |
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