束花石斛中1个新的菲类化合物

目的研究束花石斛Dendrobium chrysanthum降血糖活性的氯仿部位中的菲类成分。方法采用Sephadex LH-20、半制备高效液相色谱等多种色谱及重结晶方法进行分离纯化,根据化合物的理化性质和波谱数据鉴定结构。结果从束花石斛茎的氯仿部位中分离得到4个菲类化合物,分别鉴定为2,5-二羟基-4-甲氧基-9,10-二氢菲(1)、2,4-二羟基-5-甲氧基-9,10-二氢菲(2)、2,4,5-三羟基-9,10-二氢菲(3)、美花石斛酚A(4)。结论化合物2为新化合物,命名为束花石斛酚A;化合物1、3、4均为首次从束花石斛中分离得到。

A new phenanthrene from Dendrobium chrysanthum

Objective To investigate the phenanthrenes from chloroform fraction of Dendrobium chrysanthum. Methods Several chromatographic methods such as Sephadex LH-20 and semi-preparative HPLC were applied to isolating and purifying compounds from the antihyperglycemic chloroform fraction of D. chrysanthum. Results The structures were identified on the basis of physicochemical properties and spectroscopic data. Four compounds were isolated and identified as 2,5-dihydroxy-4-methoxy- 9,10-dihydrophenanthrene (1), 2,4-dihydroxy-5-methoxy-9,10-dihydrophenanthrene (2), 2,4,5-trihydroxy-9,10-dihydrophenanthrene (3), and loddigesiinol A (4). Conclusion Compound 2 is a new phenanthrene, named as chrysanthin A. Compounds 1, 3, and 4 are isolated from D. chrysanthum for the first time.