聚乙二醇修饰靶向纳米制剂的研究进展

由于聚乙二醇具有良好的亲水性和柔顺性，能够改善药物的药代动力学和药效学特性，将其修饰到靶向纳米制剂表面能够增加药物在体内的滞留时间和浓度，因此聚乙二醇修饰靶向纳米制剂已成为目前药剂学领域的研究热点。本文总结了靶向纳米制剂的聚乙二醇物理和化学修饰方法，将聚乙二醇-脂质衍生物物理插入纳米制剂，或将聚乙二醇与纳米制剂化学键合；并探讨了聚乙二醇参数(如聚乙二醇相对分子质量、修饰密度、空间构象)对靶向纳米制剂性质的影响，对更好地构建聚乙二醇修饰的靶向纳米制剂提供参考。

Advances in PEGylated targeted nano-preparation

Polyethylene glycol(PEG)with good hydrophilicity and flexibility can improve pharmacokinetic and pharmacodynamic properties of the nano-preparation, so PEG modification in the surface of nano-preparation can increase the in vivo residence time and concentration of drugs. At present, the targeted nano-preparation with PEG modification has become a research hotspot in the field of pharmaceutics. In this paper, the physical and chemical methods of PEG modification in targeted nano-preparation was summarized, which includes physically inserting PEG-lipid derivatives in nanostructure of targeted nano-preparation or modifying PEG with targeted nano-preparation. In addition, the influence of PEG parameters(molecular mass, modified density and spatial conformation)on properties of targeted nano-preparation was also discussed, which is important to preferably structure PEGylated targeted nano-preparation.