黏附分子与心肺转流术肺损伤

急性肺损伤是心肺转流术(cardiopulmonary by-pass,CPB)后最常见的并发症,其中白细胞在肺内的“扣留”起到了主要作用,而细胞黏附分子参与了白细胞渗出及活化的各个环节。现就有关黏附分子与CPB肺损伤关系的研究作以下综述,并探讨目前抗黏附分子在这领域的应用,旨在进一步揭示C

Adhesion molecules and cardiopulmonary bypass -induced lung injury

Cardiopulmonary bypass (CPB)-induced lung injury is the most important complication in open cardiac procedures, which affects surgical prognosis directly. During the inflammatory response, interaction between activated leukocytes and endothelial cells is mediated through the expression of three main groups of adhesion molecules: the selectins, the integrins, and the immunoglobulin superfamily. The preventive effect of anti-adhesion on CPB-induced lung injury is supposed to be the farget for farther research.