血清PSA值和前列腺结节指导前列腺穿刺活检的临床意义

目的 探讨血清ＰＳＡ浓度变化与前列腺癌及其骨转移的相关性。方法 对９３例直肠指诊异常及血清ＰＳＡ〉４ｎｇ／ｍｌ的患者，行直脾性Ｂ超引志下前列腺穿刺活检；用９９ｍＴｃ－ＭＤＰ行全身骨扫描判断有无骨。结果 ９３例中前列腺活检阳性者６０例，其中２６例扫描阳性；随血清ＰＳＡ浓度升高，前列腺阳性活检率及其远处骨转移阳性率升高。 血清ＰＳＡ升高与前列腺癌及其骨转移的发生率呈正相关。

Serum PSA level and prostatic nodule on palpation in the detection of prostatic cancer

Objective To evaluate the serum prostate specific antigen level in the detection of prostate cancer and skeletal metastasis. Methods Transrectal ultrasound guided needle biopsy of prostate was carried out for 93 subjects with an elevated serum PSA(>4.0ng/ml)and abnormal findings on rectal palpation.Whole body bone scintigraphy was undertaken for the detection of skeletal metastasis. Results 60(64.5%) of the 93 were diagnosed as prostatic cancer on biopsy of which 26 have had positive bone scan findings. Conclusions Prostate cancer and bony metastasis were more likely when serum PSA has been elevated.