| 氟代胆碱类化合物的合成及其抗肿瘤活性的研究 |
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| 引用本文： | 温鸿亮,王世真,王千里. 氟代胆碱类化合物的合成及其抗肿瘤活性的研究[J]. 沈阳药科大学学报, 2001, 18(6): 411-413 |
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| 作者姓名： | 温鸿亮 王世真 王千里 |
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| 作者单位： | 1. 北京协和医院PET中心
2. 沈阳药科大学制药工程学院 |
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| 摘 要： | 以甲二醇二对甲苯磺酸酯和重氮乙酸乙酯为起始原料 ,经取代、还原、甲基化、磷酸化反应合成了 5个氟代胆碱类化合物 ,经1H NMR及质谱确证了结构 ,并进行了抗肿瘤活性的细胞筛选实验。结果表明这 5个化合物均具有一定的抗肿瘤活性。其中FC 3对 4种癌细胞均具有较好的抑制作用 ,值得进一步进行活性筛选
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| 关 键 词： | 氟代胆碱 抗肿瘤 合成 |
| 文章编号： | 1006-2858(2001)06-0411-03 |
| 修稿时间： | 2001-04-27 |
Synthesis and anti-tumor activity of fluorocholine compounds |
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| WEN Hong liang ,WANG Shi zhen ,WANG Qian li. Synthesis and anti-tumor activity of fluorocholine compounds[J]. Journal of Shenyang Pharmaceutical University, 2001, 18(6): 411-413 |
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| Authors: | WEN Hong liang WANG Shi zhen WANG Qian li |
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| Affiliation: | WEN Hong liang 1,WANG Shi zhen 1,WANG Qian li 2 |
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| Abstract: | Five fluorocompounds were synthesized from ethyl diazoacetate or methanediol bis(4 methylbenzene sulfonate) via substitution,reduction,methylation and phosphatization. Their structures were identified by MS and 1H NMR . All of them showed anti tumor activities. In particular, compound FC 3 showed better inhibition activities to four cancer cells and it's worthy of further screening. |
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| Keywords: | fluorocompounds anti tumor synthesis |
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