Measurement of lactate-induced panic and anxiety |
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| Authors: | D J Dillon J M Gorman M R Liebowitz A J Fyer D F Klein |
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| Affiliation: | 1. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Neurology Department, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, Wuhan 430030, China;3. Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China;4. Department of Neuropsychopharmacology, Medical School of China Three Gorges University, Yichang 443002, China;1. CoRPS – Center of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands;2. Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands;3. University Medical Center Utrecht, Division Heart and Lung, Utrecht, The Netherlands;4. St. Paul''s Hospital, Heart Center, Vancouver, Canada;5. Department of Psychology, University of Southern Denmark, Odense, Denmark;6. Department of Cardiology, Odense University Hospital, Odense, Denmark;1. Steno Diabetes Center, Gentofte, Denmark;2. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland;3. Cancer Epigenetics and Biology Program, Spanish Biomedical Research Centre Network for Epidemiology and Public Health, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Barcelona, Spain;4. Institute for Research in Biomedicine, Barcelona, Spain;5. Departament de Bioquímica I Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain;6. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Spain;7. Voluntary Health Insurance Board, Dublin, Ireland;8. University of Newcastle-on-Tyne, Newcastle, UK;9. Metabolon Inc., Durham, NC, USA;10. Pintail Ltd., Blackrock, Co., Dublin, Ireland;11. Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Dublin, Ireland;1. Medical College of Wisconsin, Milwaukee, Wisconsin;2. Duke University, Durham, North Carolina;3. The Children''s Hospital of Philadelphia, Philadelphia, Pennsylvania;4. Alfred I. DuPont Hospital for Children, Wilmington, Delaware;5. Columbia University Medical Center, New York, New York;6. Boston Children''s Hospital, Boston, Massachusetts;7. University of Michigan, Ann Arbor, Michigan;8. University of Utah, Salt Lake City, Utah;9. Emory University School of Medicine, Atlanta, Georgia;10. Children''s Hospital Los Angeles, Los Angeles, California |
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| Abstract: | Acute Panic Inventory (API) scores were obtained from 26 normal controls and 89 patients with either panic disorder or agoraphobia with panic attacks before and during lactate infusions. Retrospective ratings of the patients' usual spontaneous attacks were much higher, by API, than ratings of moments of severe stress by the controls. Point of panic API scores, as well as increments of panic scores over prelactate scores, were higher for patients who experienced lactate panics than for both controls and patients who did not panic. |
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