| 双炔失碳酯对人早孕绒毛蜕膜组织细胞分泌功能的影响 |
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| 引用本文： | 刘芳,于俊荣,张凤娥,樊瑞琴,齐惠敏,王兰素,王华芝. 双炔失碳酯对人早孕绒毛蜕膜组织细胞分泌功能的影响[J]. 生殖医学杂志, 2000, 9(5): 284-288 |
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| 作者姓名： | 刘芳 于俊荣 张凤娥 樊瑞琴 齐惠敏 王兰素 王华芝 |
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| 作者单位： | 1. 河北省计划生育科学技术研究所,石家庄 050071
2. 河北医科大学第二附属医院,石家庄 050000 |
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| 基金项目： | 本课题由国家计划生育药具重点实验室资助(B2-98-5,98-19-1) |
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| 摘 要： | 本实验以绒毛、蜕膜组织细胞培养为模型 ,用放射免疫测定方法 ,观察了双炔失碳酯对绒毛、蜕膜组织细胞分泌功能的影响。结果 :培养的绒毛、蜕膜组织细胞中加入系列浓度的双炔失碳酯后 2 4和 48h,h CG、E2 、P均明显降低 (P<0 .0 1 ,P<0 .0 5 ) ,PGF2α明显增高 (P<0 .0 1 ,P<0 .0 5 )。表明 ,双炔失碳酯可直接作用于人绒毛、蜕膜组织 ,抑制h CG、E2 、P的产生 ,刺激 PGF2α的合成。结果提示 ,绒毛、蜕膜是双炔失碳酯抗早孕时 ,主要作用环节之一。
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| 关 键 词： | 双炔失碳酯 绒毛 蜕膜 内分泌功能 |
| 修稿时间： | 1999-12-01 |
The effects of anordrin on the endocrine function of chorionic and decidual cells in early human pregnancy |
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| LIU Fang,YU Jun rong,ZHANG Feng e,FAN Rui qin,QI Hui min,WANG Lan su ,WANG Hua zhi Hebei Family Planning Institute,Shijiazhuang Second Affiliated Hospital,Hebei Medical University,Shijiazhuang. The effects of anordrin on the endocrine function of chorionic and decidual cells in early human pregnancy[J]. Journal of Reproductive Medicine, 2000, 9(5): 284-288 |
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| Authors: | LIU Fang YU Jun rong ZHANG Feng e FAN Rui qin QI Hui min WANG Lan su WANG Hua zhi Hebei Family Planning Institute Shijiazhuang Second Affiliated Hospital Hebei Medical University Shijiazhuang |
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| Affiliation: | LIU Fang,YU Jun rong,ZHANG Feng e,FAN Rui qin,QI Hui min,WANG Lan su *,WANG Hua zhi * Hebei Family Planning Institute,Shijiazhuang 050071 *Second Affiliated Hospital,Hebei Medical University,Shijiazhuang 050000 |
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| Abstract: | Objectives: To examine the effects of anordrin on the endocrine function of chorionic and decidual cells in vitro and to investigate the mechanisms of termination of pregnancy of anordrin. Methods: The project was studied by using tissue cells culture and RIA. Results: Anordrin inhibited the production of hCG、E 2、P and stimulated the synthesis of PGF 2α in chorionic and/or decidual tissue cells in vitro( P<0.01,P<0.05 ). Conclusion: The results indicate that chorion and decidua serve as one of the primary sites through which anordrin exerts the effect of termination for early pregnancy. |
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| Keywords: | Anordrin Chorion Decidua Endocrine function |
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